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dc.contributor.author | Inuzuka, Tadashi | en |
dc.contributor.author | Ueda, Yoshihide | en |
dc.contributor.author | Arasawa, Soichi | en |
dc.contributor.author | Takeda, Haruhiko | en |
dc.contributor.author | Matsumoto, Tomonori | en |
dc.contributor.author | Osaki, Yukio | en |
dc.contributor.author | Uemoto, Shinji | en |
dc.contributor.author | Seno, Hiroshi | en |
dc.contributor.author | Marusawa, Hiroyuki | en |
dc.contributor.alternative | 上田, 佳秀 | ja |
dc.contributor.alternative | 上本, 伸二 | ja |
dc.contributor.alternative | 瀬尾, 智 | ja |
dc.date.accessioned | 2019-09-13T06:56:45Z | - |
dc.date.available | 2019-09-13T06:56:45Z | - |
dc.date.issued | 2018-12-24 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2433/244034 | - |
dc.description.abstract | HBV reactivation could be induced under immunosuppressive conditions in patients with resolved infection. This study aimed to clarify the viral factors associated with the pathogenesis of HBV reactivation in association with the immunosuppressive status. Whole HBV genome sequences were determined from the sera of 24 patients with HBV reactivation, including 8 cases under strong immunosuppression mediated by hematopoietic stem cell transplantation (HSCT) and 16 cases without HSCT. Ultra-deep sequencing revealed that the prevalence of genotype B and the ratio of non-synonymous to synonymous evolutionary changes in the surface (S) gene were significantly higher in non-HSCT cases than in patients with HSCT. Those non-synonymous variants included immune escape (6/16 cases) and MHC class II-restricted T-cell epitope variants (6/16 cases). Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region. In conclusion, virologic features of reactivated HBV clones differed depending on the intensity of the immunosuppressive condition. HBV reactivation triggered by immunosuppressive conditions, especially those without HSCT, was characterized by the expansion of variants associated with immune escape, MHC class II-restricted T-cell epitope alterations, and/or impaired virion secretion. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.title | Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Scientific Reports | en |
dc.identifier.volume | 8 | - |
dc.relation.doi | 10.1038/s41598-018-36093-w | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 18070 | - |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine・Research Center for Hepatitis and Immunology National Center for Global Health and Medicine, Chiba | en |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University・Research Fellow of Japan Society for the Promotion of Science | en |
dc.address | Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital | en |
dc.address | Department of Surgery, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University・Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital | en |
dc.identifier.pmid | 30584239 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 17H04158 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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