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Title: Synovial Tissue Inflammation Mediated by Autoimmune T Cells
Authors: Takeuchi, Yusuke
Hirota, Keiji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-4737-0661 (unconfirmed)
Sakaguchi, Shimon
Author's alias: 竹内, 悠介
廣田, 圭司
坂口, 志文
Keywords: autoimmune arthritis
Th17
treg cells
rheumatoid arthritis
synovial inflammation
proinflammatory cytokine
Issue Date: 21-Aug-2019
Publisher: Frontiers Media SA
Journal title: Frontiers in Immunology
Volume: 10
Thesis number: 1989
Abstract: In rheumatoid arthritis (RA), various hematopoietic and non-hematopoietic cells present in the synovial tissue secrete numerous inflammatory mediators including pro-inflammatory cytokines critical for the induction of chronic joint inflammation and bone destruction. Fibroblast-like synoviocytes (FLSs) in the non-hematopoietic cell compartment are key inflammatory cells activated in inflamed joints and driving the disease; yet how synovial tissue inflammation is modulated by autoimmune T cells is not fully understood. In this review, mainly based on recent findings with a mouse model of spontaneous autoimmune arthritis, we discuss the mechanism of Th17-mediated synovial tissue inflammation; that is, what environmental stimuli and arthritogenic self-antigens trigger arthritis, how arthritogenic T cells initiate joint inflammation by stimulating FLSs, and how the cellular sources of GM-CSF from lymphoid and tissue stromal cells in the synovium contribute to the development of arthritis. We also highlight possible plasticity of Th17 cells toward pathogenic GM-CSF producers, and the functional instability of regulatory T cells under inflammatory conditions in RA joints.
Rights: © 2019 Takeuchi, Hirota and Sakaguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
URI: http://hdl.handle.net/2433/244157
DOI(Published Version): 10.3389/fimmu.2019.01989
PubMed ID: 31497022
Appears in Collections:Journal Articles

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