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タイトル: | Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy |
著者: | Matsumoto, Kotaro ![]() ![]() Saitoh, Hiroyuki Doan, Tan Le Hoang Shiro, Ayumi Nakai, Keigo Komatsu, Aoi Tsujimoto, Masahiko Yasuda, Ryo Kawachi, Tetsuya Tajima, Toshiki Tamanoi, Fuyuhiko ![]() ![]() ![]() |
著者名の別形: | 松本, 光太郎 齋藤, 寛之 小松, 葵 辻本, 将彦 玉野井, 冬彦 |
発行日: | 30-Sep-2019 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 9 |
論文番号: | 13275 |
抄録: | Synchrotron generated monochromatic X-rays can be precisely tuned to the K-shell energy of high Z materials resulting in the release of the Auger electrons. In this work, we have employed this mechanism to destruct tumor spheroids. We first loaded gadolinium onto the surface of mesoporous silica nanoparticles (MSNs) producing gadolinium-loaded MSN (Gd-MSN). When Gd-MSN was added to the tumor spheroids, we observed efficient uptake and uniform distribution of Gd-MSN. Gd-MSN also can be taken up into cancer cells and localize to a site just outside of the cell nucleus. Exposure of the Gd-MSN containing tumor spheroids to monochromatic X-ray beams resulted in almost complete destruction. Importantly, this effect was observed at an energy level of 50.25 keV, but not with 50.0 keV. These results suggest that it is possible to use precisely tuned monochromatic X-rays to destruct tumor mass loaded with high Z materials, while sparing other cells. Our experiments point to the importance of nanoparticles to facilitate loading of gadolinium to tumor spheroids and to localize at a site close to the nucleus. Because the nanoparticles can target to tumor, our study opens up the possibility of developing a new type of radiation therapy for cancer. |
記述: | 単色X線とナノ粒子により、がん患部でX線エネルギー効果を増幅する方法の開発に成功 --オージェ電子発見から100年、放射線がん治療の新境地を開く--. 京都大学プレスリリース. 2019-10-02. |
著作権等: | © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/244189 |
DOI(出版社版): | 10.1038/s41598-019-49978-1 |
PubMed ID: | 31570738 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2019-10-02 |
出現コレクション: | 学術雑誌掲載論文等 |
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