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dc.contributor.authorSakata, Akihiko
dc.contributor.authorFushimi, Yasutaka
dc.contributor.authorOkada, Tomohisa
dc.contributor.authorArakawa, Yoshiki
dc.contributor.authorKunieda, Takeharu
dc.contributor.authorMinamiguchi, Sachiko
dc.contributor.authorKido, Aki
dc.contributor.authorSakashita, Naotaka
dc.contributor.authorMiyamoto, Susumu
dc.contributor.authorTogashi, Kaori
dc.date.accessioned2019-10-08T06:46:43Z-
dc.date.available2019-10-08T06:46:43Z-
dc.date.issued2017-9
dc.identifier.issn1053-1807
dc.identifier.issn1522-2586
dc.identifier.urihttp://hdl.handle.net/2433/244235-
dc.description.abstract[Purpose]To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor. [Materials and Methods]Institutional Review Board approval and written informed consent were obtained. Forty‐one patients with suspected brain tumors were enrolled in the study. Single‐voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T1‐weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APTmean) and the 90th percentile of APT (APT90) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant. [Results]Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT90 (r = 0.49), and between Cho/creatine (Cr) and APTmean (r = 0.65) as well as APT90 (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APTmean (r = −0.52). According to ROC curves, Cho/Cr, APTmean, APT90, demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas. [Conclusion]Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is the peer reviewed version of the following article: ['JMRI' 46(3) 732-739], which has been published in final form at https://doi.org/10.1002/jmri.25597. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.rightsThe full-text file will be made open to the public on 14 August 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
dc.subjectamide proton transfer imaging
dc.subjectchemical exchange saturation transfer
dc.subjectmagnetic resonance imaging
dc.subjectmagnetic resonance spectroscopy
dc.titleDiagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors
dc.type.niitypeJournal Article
dc.identifier.jtitleJournal of Magnetic Resonance Imaging
dc.identifier.volume46
dc.identifier.issue3
dc.identifier.spage732
dc.identifier.epage739
dc.relation.doi10.1002/jmri.25597
dc.textversionauthor
dc.identifier.pmid28252822
dc.identifier.kaken25461815
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