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Title: Locomotor-reducing activity of sesquiterpenes related to Zingiber zerumbet essential oil and hexahydrozerumbone derivatives
Authors: Ogawa, Kakuyou
Yabe, Hironobu
Kitayama, Takashi
Ito, Michiho
Author's alias: 伊藤, 美千穂
Keywords: hexahydrozerumbone
locomotor-reducing effect
Issue Date: 1-Jun-2016
Publisher: Pharmaceutical Society of Japan
Journal title: Biological and Pharmaceutical Bulletin
Volume: 39
Start page: 1077
End page: 1080
Abstract: Zerumbone derivatives 1-4 are 11-membered cyclic compounds synthesised from a sesquiterpene zerumbone obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the locomotor-reducing effects of hexahydrozerumbone derivatives 1-3 and zerumbol 4, and those of β-caryophyllene 5 and caryophyllene oxide 6, which are present in Z. zerumbet essential oil. The absence of the double bond at C6 weakened the locomotor-reducing effects. β-Caryophyllene 5 and caryophyllene oxide 6 showed locomotor-reducing effects in mice at 4.5×10⁻³ mg/cage. Moreover, locomotor activity increased significantly at 0.45 mg/cage of caryophyllene oxide 6.
Rights: © 2016 The Pharmaceutical Society of Japan
DOI(Published Version): 10.1248/bpb.b16-00141
PubMed ID: 27251513
Appears in Collections:Journal Articles

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