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タイトル: | Inhalation administration of the sesquiterpenoid aristolen-1(10)-en-9-ol from Nardostachys chinensis has a sedative effect via the GABAergic system |
著者: | Takemoto, Hiroaki Ito, Michiho https://orcid.org/0000-0001-9821-0628 (unconfirmed) Asada, Yoshihisa Kobayashi, Yoshinori |
著者名の別形: | 伊藤, 美千穂 |
キーワード: | Nardostachys chinensis - Valerianaceae - aristolen-1(10)-en-9-ol - inhalation administration - sedation - GABAergic system |
発行日: | 2015 |
出版者: | Georg Thieme Verlag KG |
誌名: | Planta Medica |
巻: | 81 |
号: | 5 |
開始ページ: | 343 |
終了ページ: | 347 |
抄録: | Spikenard, the dried roots of Nardostachys chinensis, contains sesquiterpenoids and is widely used as an herbal tranquilizer. We previously demonstrated that spikenard vapor showed a sedative effect when administered by inhalation, and we identified hydrocarbon sesquiterpenoids as active components. Here we investigated the other components that contribute to the effects of spikenard. Six oxygenated sesquiterpenoids, including aristolane- and guaiane-types, were isolated from an acetone extract of spikenard. We evaluated the sedative activities of these oxygenated compounds using an inhalation administration method in a caffeine-treated excitatory mouse model. We identified aristolen-1(10)-en-9-ol and patchouli alcohol as highly effective sedative components. These compounds inhibited locomotion in mice by approximately 60 % at a dose of 300 µg/cage. In addition, aristolen-1(10)-en-9-ol prolonged pentobarbital-induced sleep to the same extent as 1 mg/kg diazepam. This effect completely disappeared with the administration of the GABAA-benzodiazepine receptor antagonist flumazenil (3 mg/kg), suggesting that the sedative effect of aristolen-1(10)-en-9-ol is expressed via the GABAergic system. Furthermore, differently from diazepam, inhalation of aristolen-1(10)-en-9-ol for 1 h did not affect the motor coordination in the rota-rod test. In the present study, we identified active components and provided evidence supporting the traditional sedative use of spikenard. Our research suggests that aristolen-1(10)-en-9-ol may be an effective aromatherapy, providing mild sedation. |
著作権等: | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. 許諾条件に基づいて掲載しています。 |
URI: | http://hdl.handle.net/2433/244287 |
DOI(出版社版): | 10.1055/s-0035-1545725 |
PubMed ID: | 25798643 |
出現コレクション: | 学術雑誌掲載論文等 |
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