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Title: The atypical social brain network in autism: Advances in structural and functional MRI studies
Authors: Sato, Wataru  KAKEN_id  orcid https://orcid.org/0000-0002-5335-1272 (unconfirmed)
Uono, Shota  KAKEN_id
Author's alias: 佐藤, 弥
魚野, 翔太
Keywords: autism spectrum disorder
default mode network
functional connectivity
gray matter volume
social brain network
Issue Date: 1-Aug-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Journal title: Current Opinion in Neurology
Volume: 32
Issue: 4
Start page: 617
End page: 621
Abstract: Purpose of review: To review advances in structural and functional MRI studies regarding the neural underpinnings of social atypicalities in autism spectrum disorder (ASD). Recent findings: According to the hypothesis that the social brain network, which includes brain regions, such as the amygdala and superior temporal sulcus, may be atypical in ASD, recent structural MRI studies have identified regional gray matter volume abnormalities in the social brain regions in ASD groups compared with the typically developing groups. Studies evaluating gray matter volume covariance and white matter volume/integrity suggested network-level abnormalities associated with the social brain regions. Recent functional MRI studies assessing resting-state neural activity showed reduced functional connectivity among the social brain regions in individuals with ASD compared with typically developing groups. Similarly, task-based functional MRI studies recently revealed a reduction in regional activity and intraregional functional coupling in the social brain regions during the processing of social stimuli in individuals with ASD. Summary: These structural and functional MRI studies provide supportive evidence for the hypothesis that an atypical social brain network underlies behavioral social problems in ASD.
Rights: © 2019 Wolters Kluwer Health, Inc. All rights resereved. This is a non-final version of an article published in final form in Sato W. and Uono S. The atypical social brain network in autism: Advances in structural and functional MRI studies. Current Opinion in Neurology 2019 32(4): 617-621.
The full-text file will be made open to the public on 1 August 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/244291
DOI(Published Version): 10.1097/WCO.0000000000000713
PubMed ID: 31135458
Appears in Collections:Journal Articles

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