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タイトル: | 術前化学療法および根治的膀胱全摘除術から4年間無再発の膀胱 cT3bN2M0 Pleomorphic giant cell carcinomaの1例 |
その他のタイトル: | A Case Of cT3bN2M0 Pleomorphic Giant Cell Carcinoma of the Bladder without Recurrence after Neoadjuvant Chemotherapy and Radical Cystectomy for 4 Years |
著者: | 木村, 博子 植村, 祐一 恵, 謙 橘, 充弘 福澤, 重樹 |
著者名の別形: | Kimura, Hiroko Uemura, Yuichi Megumi, Yuzuru Tachibana, Mitsuhiro Fukuzawa, Shigeki |
キーワード: | Pleomorphic giant cell carcinoma Bladder cancer |
発行日: | 30-Sep-2019 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 65 |
号: | 9 |
開始ページ: | 377 |
終了ページ: | 380 |
抄録: | Pleomorphic giant cell carcinoma of the bladder is a highly malignant subtype and its prognosis is very poor. Among 22 previously reported cases, 14 cases were diagnosed as muscle-invasive tumors and the 10 patients died within 1.5 years after the initial diagnosis. We herein report a long-surviving patient with cT3bN2M0 pleomorphic giant cell carcinoma of the bladder without recurrence. A 73-year-old man presented with macroscopic hematuria and cystoscopy revealed a papillary nodular tumor 45 millimeters in diameter at the right bladder wall. Bilateral external iliac lymph node metastases were found on computed tomography (CT) and magnetic resonance imaging (MRI). The histopathological diagnosis of the transurethral resection specimen was pleomorphic giant cell urothelial carcinoma, high-grade, G3, pT2 or higher. The pleomorphic giant cells were composed of large epithelioid cells with single or multiple bizarre nuclei. The patient underwent 2 cycles of neoadjuvant chemotherapy using gemcitabine and cisplatin. Follow-up CT and MRI revealed disappearance of iliac lymph node matastases. Laparoscopic radical cystectomy and lymphadenectomy were performed. The histopathological diagnosis was pleomorphic giant cell urothelial carcinoma, ypT3aN0M0, RM0. Giant cells were found in 70% of the tumor. No recurrence has been found for 4 years after surgery. If neoadjuvant chemotherapy is effective, long-term survival without recurrence may be possible after radical cystectomy even in cases of muscle-invasive or N2 pleomorphic giant cell carcinoma of the bladder. |
著作権等: | 許諾条件により本文は2020/10/01に公開 |
DOI: | 10.14989/ActaUrolJap_65_9_377 |
URI: | http://hdl.handle.net/2433/244684 |
PubMed ID: | 31697880 |
出現コレクション: | Vol.65 No.9 |
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