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Title: 腹膜播種転移を伴う進行性腎細胞癌に対するニボルマブの治療効果
Other Titles: Clinical Effect of Nivolumab on Advanced Renal Cell Carcinoma with Peritoneal Metastasis
Authors: 飛田, 卓哉  KAKEN_name
山﨑, 俊成  KAKEN_name
坂野, 遼  KAKEN_name
渕上, 靖史  KAKEN_name
八田原, 広大  KAKEN_name
藤原, 真希  KAKEN_name
鈴木, 良輔  KAKEN_name
北, 悠希  KAKEN_name
吉野, 喬之  KAKEN_name
後藤, 崇之  KAKEN_name
澤田, 篤郎  KAKEN_name
赤松, 秀輔  KAKEN_name
齊藤, 亮一  KAKEN_name
小林, 恭  KAKEN_name
井上, 貴博  KAKEN_name
小川, 修  KAKEN_name
Author's alias: Hida, Takuya
Yamasaki, Toshinari
Banno, Haruka
Fuchigami, Yasushi
Hattahara, Kodai
Fujiwara, Maki
Suzuki, Ryosuke
Kita, Yuki
Yoshino, Takayuki
Goto, Takayuki
Sawada, Atsuro
Akamatsu, Shusuke
Saito, Ryoichi
Kobayashi, Takashi
Inoue, Takahiro
Ogawa, Osamu
Keywords: Nivolumab
Peritoneal metastasis
Renal cell carcinoma
Issue Date: 31-Oct-2019
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要 = Acta urologica Japonica
Volume: 65
Issue: 10
Start page: 413
End page: 419
Abstract: Peritoneal dissemination or metastasis is a relatively rare presentation of renal cell carcinoma. We report four cases of advanced renal cell carcinoma with peritoneal metastases treated with nivolumab. Three cases showed an objective response in the metastatic lesions including peritoneal sites. After nivolumab administration, the computed tomography scan showed a transient enlargement of peritoneal lesions in two cases, which could be considered as pseudoprogression. Temporal changes of neutrophil-tolymphocyte ratio, C-reactive protein, and eosinophil ratio during the clinical course reflected the treatment effect of nivolumab in these patients, indicating that these could be potential biomarkers of the response. To our knowledge, this is the first case series showing therapeutic activity of nivolumab against peritoneal metastases in patients with renal cell carcinoma.
Rights: 許諾条件により本文は2020/11/01に公開
DOI: 10.14989/ActaUrolJap_65_10_413
URI: http://hdl.handle.net/2433/244695
PubMed ID: 31697887
Appears in Collections:Vol.65 No.10

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