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dc.contributor.author | Seko, Yuta | en |
dc.contributor.author | Kato, Takao | en |
dc.contributor.author | Shiba, Masayuki | en |
dc.contributor.author | Morita, Yusuke | en |
dc.contributor.author | Yamaji, Yuhei | en |
dc.contributor.author | Haruna, Yoshizumi | en |
dc.contributor.author | Nakane, Eisaku | en |
dc.contributor.author | Hayashi, Hideyuki | en |
dc.contributor.author | Haruna, Tetsuya | en |
dc.contributor.author | Inoko, Moriaki | en |
dc.contributor.alternative | 加藤, 貴雄 | ja |
dc.date.accessioned | 2019-11-26T01:46:53Z | - |
dc.date.available | 2019-11-26T01:46:53Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | http://hdl.handle.net/2433/244827 | - |
dc.description.abstract | Objective We aimed to evaluate the association of the severity of left ventricular (LV) diastolic dysfunction with long-term outcomes in patients with normal ejection fraction. Design Retrospective study. Setting A single centre in Japan. Participants We included 3576 patients who underwent both scheduled transthoracic echocardiography and ECG between 1 January and 31 December 2013, in a hospital-based population after excluding valvular diseases or low ejection fraction (<50%) or atrial fibrillation and categorised them into three groups: septal tissue Doppler early diastolic mitral annular velocity (e′)≥7 (without relaxation disorder, n=1593), e′<7 and early mitral inflow velocity (E)/e′≤14 (with relaxation disorder and normal LV end-diastolic pressure, n=1337) and e′<7 and E/e′>14 (with relaxation disorder and high LV end-diastolic pressure, n=646). Primary and secondary outcome measures The primary outcome measure was a composite of all-cause death and major adverse cardiac events (MACE). The secondary outcome measure were all-cause death and MACE, separately. Results The cumulative 3-year incidences of the primary outcome measures were significantly higher in the e′<7 and E/e′≤14 (19.0%) and e′<7 and E/e′>14 group (23.4%) than those for the e′≥7 group (13.0%; p<0.001). After adjusting for confounders, the excess 3-year risk of primary outcome for the groups with e′<7 and E/e′≤14 related to e′≥7 (HR: 1.24; 95% CI 1.02 to 1.52) and e′<7 and E/e′>14 related to e′<7 (HR: 1.57; 95% CI 1.28 to 1.94) were significant. The severity of diastolic dysfunction was associated with incrementally higher risk for primary outcomes (p<0.001). Conclusion The severity of LV diastolic dysfunction using e′<7 and E/e′>14 was associated with the long-term prognosis in patients with normal ejection fraction in an incremental fashion. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ | en |
dc.rights | © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | en |
dc.title | Association of the low e’ and high E/e’ with long-term outcomes in patients with normal ejection fraction | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | BMJ Open | en |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 11 | - |
dc.relation.doi | 10.1136/bmjopen-2019-032663 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e032663 | - |
dc.address | Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Faculty of Medicine | en |
dc.address | Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Faculty of Medicine | en |
dc.address | Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Faculty of Medicine | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.address | Cardiovascular Center, Kitano Hospital | en |
dc.identifier.pmid | 31753896 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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