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Title: AMPA receptors in the synapse turnover by monomer diffusion
Authors: Morise, Jyoji  kyouindb  KAKEN_id
Suzuki, Kenichi G. N.
Kitagawa, Ayaka
Wakazono, Yoshihiko
Takamiya, Kogo
Tsunoyama, Taka A.
Nemoto, Yuri L.
Takematsu, Hiromu
Kusumi, Akihiro
Oka, Shogo  kyouindb  KAKEN_id
Author's alias: 森瀬, 譲二
鈴木, 健一
楠見, 明弘
岡, 昌吾
Issue Date: 20-Nov-2019
Publisher: Springer Nature
Journal title: Nature Communications
Volume: 10
Thesis number: 5245
Abstract: The number and subunit compositions of AMPA receptors (AMPARs), hetero- or homotetramers composed of four subunits GluA1–4, in the synapse is carefully tuned to sustain basic synaptic activity. This enables stimulation-induced synaptic plasticity, which is central to learning and memory. The AMPAR tetramers have been widely believed to be stable from their formation in the endoplasmic reticulum until their proteolytic decomposition. However, by observing GluA1 and GluA2 at the level of single molecules, we find that the homo- and heterotetramers are metastable, instantaneously falling apart into monomers, dimers, or trimers (in 100 and 200 ms, respectively), which readily form tetramers again. In the dendritic plasma membrane, GluA1 and GluA2 monomers and dimers are far more mobile than tetramers and enter and exit from the synaptic regions. We conclude that AMPAR turnover by lateral diffusion, essential for sustaining synaptic function, is largely done by monomers of AMPAR subunits, rather than preformed tetramers.
Description: 記憶の鍵となる受容体を働かせる仕組みを解明 --4つのパーツを0.1秒毎に組み立て直して働かせるメカニズム--. 京都大学プレスリリース. 2019-11-26.
Rights: © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/244829
DOI(Published Version): 10.1038/s41467-019-13229-8
PubMed ID: 31748519
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2019-11-26-0
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