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dc.contributor.authorHermawan, Idamen
dc.contributor.authorHiga, Mikakoen
dc.contributor.authorHutabarat, Philipus Uli Basaen
dc.contributor.authorFujiwara, Takeshien
dc.contributor.authorAkiyama, Kiyotakaen
dc.contributor.authorKanamoto, Akihikoen
dc.contributor.authorHaruyama, Takahiroen
dc.contributor.authorKobayashi, Nobuyukien
dc.contributor.authorHigashi, Masahiroen
dc.contributor.authorSuda, Shoichiroen
dc.contributor.authorTanaka, Junichien
dc.contributor.alternative東, 雅大ja
dc.date.accessioned2020-01-28T03:00:16Z-
dc.date.available2020-01-28T03:00:16Z-
dc.date.issued2019-06-
dc.identifier.issn1660-3397-
dc.identifier.urihttp://hdl.handle.net/2433/245467-
dc.description.abstractOn our quest for new bioactive molecules from marine sources, two cyclic imines (1, 2) were isolated from a dinoflagellate extract, inhibiting the growth of the respiratory syncytial virus (RSV). Compound 1 was identified as a known molecule portimine, while 2 was elucidated to be a new cyclic imine, named kabirimine. The absolute stereochemistry of 1 was determined by crystallographic work and chiral derivatization, whereas the structure of 2 was elucidated by means of spectroscopic analysis and computational study on all the possible isomers. Compound 1 showed potent cytotoxicity (CC₅₀ < 0.097 µM) against HEp2 cells, while 2 exhibited moderate antiviral activity against RSV with IC₅₀ = 4.20 µM (95% CI 3.31–5.33).en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI AGen
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectcyclic imineen
dc.subjectdinoflagellateen
dc.subjectrespiratory syncytial virus (RSV)en
dc.subjectportimineen
dc.subjectkabirimineen
dc.titleKabirimine, a New Cyclic Imine from an Okinawan Dinoflagellateen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleMarine drugsen
dc.identifier.volume17-
dc.identifier.issue6-
dc.relation.doi10.3390/md17060353-
dc.textversionpublisher-
dc.identifier.artnum353-
dc.addressGraduate School of Engineering and Science, University of the Ryukyusen
dc.addressGraduate School of Engineering and Science, University of the Ryukyusen
dc.addressGraduate School of Engineering and Science, University of the Ryukyusen
dc.addressOP Bio Factory Co., Ltd.en
dc.addressOP Bio Factory Co., Ltd.en
dc.addressOP Bio Factory Co., Ltd.en
dc.addressCentral Research Center, AVSS Corporationen
dc.addressCentral Research Center, AVSS Corporationen
dc.addressDepartment of Molecular Engineering, Kyoto Universityen
dc.addressDepartment of Chemistry, Biology and Marine Science, University of the Ryukyusen
dc.addressDepartment of Chemistry, Biology and Marine Science, University of the Ryukyusen
dc.identifier.pmid31200525-
dcterms.accessRightsopen access-
datacite.awardNumberJP16KT0165-
datacite.awardNumberJP17K05757-
datacite.awardNumberJP18H04657-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
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