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タイトル: | ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum |
著者: | Tone, Takuya Nakayama, Kazuhisa https://orcid.org/0000-0001-7701-7183 (unconfirmed) Takatsu, Hiroyuki Shin, Hye Won |
著者名の別形: | 中山, 和久 髙津, 宏之 申, 惠媛 |
キーワード: | E1-E2 ATPase flippase lipid bilayer membrane P4-ATPase |
発行日: | Feb-2020 |
出版者: | Wiley |
誌名: | FEBS Letters |
巻: | 594 |
号: | 3 |
開始ページ: | 412 |
終了ページ: | 423 |
抄録: | P4‐ATPases belonging to the P‐type ATPase superfamily mediate active transport of phospholipids across cellular membranes. Most P4‐ATPases, except ATP9A and ATP9B proteins, form heteromeric complexes with CDC50 proteins, which are required for transport of P4‐ATPases from the endoplasmic reticulum (ER) to their final destinations. P‐type ATPases form autophosphorylated intermediates during the ATPase reaction cycle. However, the association of the catalytic cycle of P4‐ATPases with their transport from the ER and their cellular localization has not been studied. Here, we show that transport of ATP9 and ATP11 proteins as well as that of ATP10A from the ER depends on the ATPase catalytic cycle, suggesting that conformational changes in P4‐ATPases during the catalytic cycle are crucial for their transport from the ER. |
著作権等: | This is the peer reviewed version of the following article: [FEBS Letters, 594(3), 415-423], which has been published in final form at https://doi.org/10.1002/1873-3468.13629. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. The full-text file will be made open to the public on 14 October 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/245891 |
DOI(出版社版): | 10.1002/1873-3468.13629 |
PubMed ID: | 31571211 |
出現コレクション: | 学術雑誌掲載論文等 |
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