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タイトル: | Night Monkey Hybrids Exhibit De Novo Genomic and Karyotypic Alterations: The First Such Case in Primates |
著者: | Hirai, Hirohisa Hirai, Yuriko Morimoto, Mayumi Kaneko, Akihisa Kamanaka, Yoshiro Koga, Akihiko |
著者名の別形: | 古賀, 章彦 |
キーワード: | interspecies hybridization chromosome paint analysis trisomy reciprocal translocation mosaicism hybridization effect |
発行日: | 1-Apr-2017 |
出版者: | Oxford University Press (OUP) |
誌名: | Genome biology and evolution |
巻: | 9 |
号: | 4 |
開始ページ: | 945 |
終了ページ: | 955 |
抄録: | Using molecular chromosomal analyses, we discovered night monkey hybrids produced in captivity from matings between a female Aotus azarae boliviensis (2n = 50) and a male Aotus lemurinus griseimembra (2n = 53). The parents produced seven offspring in total, including one male and six females-a pattern consistent with Haldane's rule. Chromosomal studies were conducted on four of the hybrid offspring. Two of them showed relatively "simple" mixture karyotypes, including different chromosome numbers (2n = 51, 52), which were formed because of a heteromorphic autosome pair in the father (n = 26, 27). The other two hybrid monkeys exhibited de novo genomic and karyotypic alterations. Detailed analysis of the alterations revealed that one individual carried a mixture karyotype of the two parental species and an X chromosome trisomy (53, XXX). The second individual displayed trisomy of chromosome 18 (52, XX, +18) and a reciprocal translocation between autosomes 21 and 23 (52, XX, +18, t(21;23)). Interestingly, the second monkey exhibited mosaicism among blood cells (mos52, XX, +18[87]/52, XX, +18, t(21;23)[85]), but only a single karyotype (52, XX, +18) in skin fibroblast cells. The X- and 18-trisomies were derived from a doubling of the mother's chromosomes in early embryonic cell division, and the reciprocal translocation likely developed in the bone marrow of the offspring, considering that it was observed only in blood cells. Such occurrence of trisomies in hybrid individuals is a unique finding in placental mammals. |
著作権等: | © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
URI: | http://hdl.handle.net/2433/250052 |
DOI(出版社版): | 10.1093/gbe/evx058 |
PubMed ID: | 28369492 |
出現コレクション: | 学術雑誌掲載論文等 |
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