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Title: Complete fusion of a transposon and herpesvirus created the Teratorn mobile element in medaka fish
Authors: Inoue, Yusuke
Saga, Tomonori
Aikawa, Takumi
Kumagai, Masahiko
Shimada, Atsuko
Kawaguchi, Yasushi
Naruse, Kiyoshi
Morishita, Shinichi
Koga, Akihiko  kyouindb  KAKEN_id
Takeda, Hiroyuki
Author's alias: 井上, 雄介
熊谷, 真彦
島田, 敦子
川口, 寧
成瀬, 清
森下, 真一
古賀, 章彦
武田, 洋幸
Keywords: Evolutionary genetics
Mobile elements
Viral evolution
Issue Date: 15-Sep-2017
Publisher: Springer Nature
Journal title: Nature Communications
Volume: 8
Thesis number: 551
Abstract: Mobile genetic elements (e.g., transposable elements and viruses) display significant diversity with various life cycles, but how novel elements emerge remains obscure. Here, we report a giant (180-kb long) transposon, Teratorn, originally identified in the genome of medaka, Oryzias latipes. Teratorn belongs to the piggyBac superfamily and retains the transposition activity. Remarkably, Teratorn is largely derived from a herpesvirus of the Alloherpesviridae family that could infect fish and amphibians. Genomic survey of Teratorn-like elements reveals that some of them exist as a fused form between piggyBac transposon and herpesvirus genome in teleosts, implying the generality of transposon-herpesvirus fusion. We propose that Teratorn was created by a unique fusion of DNA transposon and herpesvirus, leading to life cycle shift. Our study supports the idea that recombination is the key event in generation of novel mobile genetic elements.
Rights: © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/250073
DOI(Published Version): 10.1038/s41467-017-00527-2
PubMed ID: 28916771
Appears in Collections:Journal Articles

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