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dc.contributor.author | Minamino-Muta, Eri | en |
dc.contributor.author | Kato, Takao | en |
dc.contributor.author | Morimoto, Takeshi | en |
dc.contributor.author | Taniguchi, Tomohiko | en |
dc.contributor.author | Ando, Kenji | en |
dc.contributor.author | Kanamori, Norio | en |
dc.contributor.author | Murata, Koichiro | en |
dc.contributor.author | Kitai, Takeshi | en |
dc.contributor.author | Kawase, Yuichi | en |
dc.contributor.author | Miyake, Makoto | en |
dc.contributor.author | Izumi, Chisato | en |
dc.contributor.author | Mitsuoka, Hirokazu | en |
dc.contributor.author | Kato, Masashi | en |
dc.contributor.author | Hirano, Yutaka | en |
dc.contributor.author | Matsuda, Shintaro | en |
dc.contributor.author | Nagao, Kazuya | en |
dc.contributor.author | Murakami, Tomoyuki | en |
dc.contributor.author | Takeuchi, Yasuyo | en |
dc.contributor.author | Yamane, Keiichiro | en |
dc.contributor.author | Toyofuku, Mamoru | en |
dc.contributor.author | Ishii, Mitsuru | en |
dc.contributor.author | Inoko, Moriaki | en |
dc.contributor.author | Ikeda, Tomoyuki | en |
dc.contributor.author | Ishii, Katsuhisa | en |
dc.contributor.author | Hotta, Kozo | en |
dc.contributor.author | Jinnai, Toshikazu | en |
dc.contributor.author | Kato, Yoshihiro | en |
dc.contributor.author | Inuzuka, Yasutaka | en |
dc.contributor.author | Maeda, Chiyo | en |
dc.contributor.author | Morikami, Yuko | en |
dc.contributor.author | Saito, Naritatsu | en |
dc.contributor.author | Minatoya, Kenji | en |
dc.contributor.author | Kimura, Takeshi | en |
dc.contributor.alternative | 加藤, 貴雄 | ja |
dc.contributor.alternative | 齋藤, 成達 | ja |
dc.contributor.alternative | 湊谷, 謙司 | ja |
dc.contributor.alternative | 木村, 剛 | ja |
dc.date.accessioned | 2020-04-22T07:37:05Z | - |
dc.date.available | 2020-04-22T07:37:05Z | - |
dc.date.issued | 2020-04-01 | - |
dc.identifier.issn | 2058-5225 | - |
dc.identifier.issn | 2058-1742 | - |
dc.identifier.uri | http://hdl.handle.net/2433/250453 | - |
dc.description.abstract | Aims: Early aortic valve replacement (AVR) might be beneficial in selected high-risk asymptomatic patients with severe aortic stenosis (AS), considering their poor prognosis when managed conservatively. This study aimed to develop and validate a clinical scoring system to predict AS-related events within 1 year after diagnosis in asymptomatic severe AS patients. Methods and results: We analysed 1274 asymptomatic severe AS patients derived from a retrospective multicentre registry enrolling consecutive patients with severe AS in Japan (CURRENT AS registry), who were managed conservatively and completed 1-year follow-up without AVR. From a randomly assigned derivation set (N = 849), we developed CURRENT AS risk score for the AS-related event (a composite of AS-related death and heart failure hospitalization) within 1 year using a multivariable logistic regression model. The risk score comprised independent risk predictors including left ventricular ejection fraction <60%, haemoglobin ≤11.0 g/dL, chronic lung disease (2 points), diabetes mellitus, haemodialysis, and any concomitant valve disease (1 point). The predictive accuracy of the model was good with the area under the curve of 0.79 and 0.77 in the derivation and validation sets (N = 425). In the validation set, the 1-year incidence of AS-related events was much higher in patients with score ≥2 than in patients with score ≤1 (Score 0: 2.2%, Score 1: 1.9%, Score 2: 13.4%, Score 3: 14.3%, and Score ≥4: 22.7%, P < 0.001). Conclusion: The CURRENT-AS risk score integrating clinical and echocardiographic factors well-predicted the risk of AS-related events at 1 year in asymptomatic patients with severe AS and was validated internally. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press (OUP) | en |
dc.rights | This is a pre-copyedited, author-produced PDF of an article accepted for publication in 'European Heart Journal - Quality of Care and Clinical Outcomes' following peer review. The version of record [European Heart Journal - Quality of Care and Clinical Outcomes (2020) 6, 166–174] is available online at: https://doi.org/10.1093/ehjqcco/qcz044. | en |
dc.rights | The full-text file will be made open to the public on 19 August 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Severe aortic stenosis | en |
dc.subject | Asymptomatic | en |
dc.subject | Risk prediction model | en |
dc.title | A Risk Prediction Model in Asymptomatic Patients with Severe Aortic Stenosis under Conservative Management: CURRENT-AS risk score | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | European Heart Journal - Quality of Care and Clinical Outcomes | en |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 166 | - |
dc.identifier.epage | 174 | - |
dc.relation.doi | 10.1093/ehjqcco/qcz044 | - |
dc.textversion | author | - |
dc.identifier.pmid | 31386103 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-08-19 | - |
dc.identifier.pissn | 2058-5225 | - |
dc.identifier.eissn | 2058-1742 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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