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Title: Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image
Authors: Sawai, Yuka
Miyata, Manabu  kyouindb  KAKEN_id  orcid (unconfirmed)
Uji, Akihito
Ooto, Sotaro
Tamura, Hiroshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Ueda-Arakawa, Naoko
Muraoka, Yuki
Miyake, Masahiro  kyouindb  KAKEN_id
Takahashi, Ayako  kyouindb  KAKEN_id
Kawashima, Yu
Kadomoto, Shin
Oritani, Yasuyuki
Kawai, Kentaro
Yamashiro, Kenji
Tsujikawa, Akitaka
Author's alias: 澤井, 結花
宮田, 学
宇治, 彰人
大音, 壮太郎
田村, 寛
上田, 奈央子
村岡, 勇貴
三宅, 正裕
高橋, 綾子
川島, 祐
加登本, 伸
織谷, 康之
河合, 健太郎
山城, 健児
辻川, 明孝
Keywords: Medical research
Structural biology
Issue Date: 10-Apr-2020
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 10
Thesis number: 6172
Abstract: Quality of single optical coherence tomography angiography (OCTA) images of myopic choroidal neovascularisation (mCNV) is poorer than in averaged images, although obtaining averaged images takes much time. This study evaluated the clinical usefulness of novel denoising process for depicting mCNV. This study included 20 eyes of 20 patients with mCNV. Ten en face images taken in a 3 × 3 mm macular cube were obtained from outer-retina-to-choriocapillaris layer. Three image types were prepared for analysis; single images before and after the denoising process accomplished deep learning (single and denoising groups, respectively) and up to 10 images were averaged (averaging group). Pairwise comparisons showed vessel density, vessel length density, and fractal dimension (FD) were higher; whereas, vessel density index (VDI) was lower in single group than in denoising and averaging groups. Detectable CNV indices, contrast-to-nose ratio, and CNV diagnostic scores were higher in denoising and averaging groups than in single group. No significant differences were detected in VDI, FD, or CNV diagnostic scores between denoising and averaging groups. The denoising process can utilise single OCTA images to provide results comparable to averaged OCTA images, which is clinically useful for shortening examination times with quality similar to averaging.
Rights: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41598-020-62607-6
PubMed ID: 32277172
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