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Title: Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish
Authors: Suzuki, Shiho
Kimura, Ryo  KAKEN_id  orcid https://orcid.org/0000-0003-3220-991X (unconfirmed)
Maegawa, Shingo  kyouindb  KAKEN_id
Nakata, Masatoshi
Hagiwara, Masatoshi  kyouindb  KAKEN_id
Author's alias: 鈴木, 志穂
木村, 亮
前川, 真吾
中田, 昌利
萩原, 正敏
Keywords: Attention deficit-hyperactivity disorder (ADHD)
Behavior
Lipid metabolism
Methylphenidate
Atomoxetine
Zebrafish
Transcriptome
Issue Date: 6-May-2020
Publisher: Springer Nature
Journal title: Molecular Brain
Volume: 13
Thesis number: 70
Abstract: Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxetine (ATX) are commonly prescribed for the treatment of ADHD. In the present study, we examined the behavioral and brain transcriptome changes in MPH-treated and ATX-treated zebrafish. In behavioral analysis, zebrafish showed opposite response to each treatment. MPH-treated fish showed higher anxiety-like behavior while ATX-treated fish showed lower anxiety-like behavior. Further, we performed RNA sequencing analysis of zebrafish brain to elucidate the underlying biological pathways associated with MPH and ATX treatment. Interestingly, we found that shared differentially expressed genes in MPH-treated and ATX-treated fish were instrumental in cholesterol biosynthesis pathway and were regulated in opposite manner. Our findings highlight the contrast between MTH and ATX, and may suggest the alterations in clinical practice for these medications and drug development for ADHD.
Description: 2種類のADHD治療薬が対照的な作用を持つことを発見 --ゼブラフィッシュで行動や脳での働きを探る--. 京都大学プレスリリース. 2020-05-18.
Rights: © The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
URI: http://hdl.handle.net/2433/250824
DOI(Published Version): 10.1186/s13041-020-00614-4
PubMed ID: 32375837
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2020-05-18-0
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