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dc.contributor.author | Koga, Akihiko | en |
dc.contributor.author | Hisakawa, Chiemi | en |
dc.contributor.author | Yoshizawa, Miki | en |
dc.contributor.alternative | 古賀, 章彦 | ja |
dc.contributor.alternative | 久川, 智恵美 | ja |
dc.contributor.alternative | 吉澤, 未来 | ja |
dc.date.accessioned | 2020-05-26T06:29:39Z | - |
dc.date.available | 2020-05-26T06:29:39Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0831-2796 | - |
dc.identifier.uri | http://hdl.handle.net/2433/250995 | - |
dc.description | シャム猫のような体色パターンをもつマントヒヒの遺伝子変異を同定 --メラニン合成を担う酵素の遺伝子が変化--. 京都大学プレスリリース. 2020-03-17. | ja |
dc.description.abstract | An infant hamadryas baboon exhibiting an albino phenotype —white body hair and red eyes— was born to parents with wild-type body color. Pigmentation on some parts of its body surfaced during childhood and progressed with age. This baboon in adulthood has gray hair on parts of its body, such as the tail, distal portion of the legs, and face, with the remainder being white. This pigmentation pattern resembles that of the Siamese cat and the Himalayan variants of the mouse and the mink. The distinguishing phenotypes in these animals are known to be caused by a temperature-sensitive activity of tyrosinase, an enzyme essential for biosynthesis of melanin. We sequenced all the five exons of the tyrosinase (<i>TYR</i>) gene of this albino baboon, which were amplified by PCR, and found a base substitution leading to alteration of the 365th amino acid from Ala to Thr. Tyrosinase requires copper as a cofactor for its enzyme function. It has two copper-binding sites, the second of which contains His residues in positions 363 and 367 that are critical to its function. Thus, p.(Ala365Thr) due to a mutation in the <i>TYR</i> gene is a likely candidate for the cause of the albino phenotype in this baboon. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Canadian Science Publishing | en |
dc.rights | Copyright remains with the author(s) or their institution(s). This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. | en |
dc.subject | albinism | en |
dc.subject | melanin | en |
dc.subject | body color | en |
dc.subject | primate | en |
dc.subject | Old World monkey | en |
dc.title | Baboon bearing resemblance in pigmentation pattern to Siamese cat carries a missense mutation in the tyrosinase gene | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Genome | en |
dc.identifier.volume | 63 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 275 | - |
dc.identifier.epage | 279 | - |
dc.relation.doi | 10.1139/gen-2020-0003 | - |
dc.textversion | publisher | - |
dc.address | Primate Research Institute, Kyoto University | en |
dc.address | Wanpark Kochi Animal Land | en |
dc.address | Wanpark Kochi Animal Land | en |
dc.identifier.pmid | 32053406 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2020-03-17 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 18K19362 | - |
datacite.awardNumber | 19H03311 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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