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Title: 二次治療としてのアムルビシンが効果を示した前立腺小細胞癌の1例
Other Titles: The Efficacy of Amrubicin Therapy as a Second Line Treatment in Patients with Small Cell Carcinoma of the Prostate : A Case Report
Authors: 大澤, 華織  KAKEN_name
柚原, 一哉  KAKEN_name
小鷹, 博人  KAKEN_name
加藤, 大貴  KAKEN_name
高井, 学  KAKEN_name
飯沼, 光司  KAKEN_name
中根, 慶太  KAKEN_name
岡本, 清尚  KAKEN_name
古家, 琢也  KAKEN_name
Author's alias: Ozawa, Kaori
Yuhara, Kazuya
Kotaka, Hiroto
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Nakane, Keita
Okamoto, Kiyohisa
Koie, Takuya
Keywords: Prostate cancer
Small cell carcinoma of the prostate
Issue Date: 30-Apr-2020
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 66
Issue: 4
Start page: 121
End page: 125
Abstract: A 68-year-old man was diagnosed with prostate cancer (initial serum prostate specific antigen [PSA] 389 ng/ml, stage cT4N1M1c, Gleason score 5+4), and androgen deprivation therapy was initiated. Despite the low serum PSA level, he developed postrenal acute kidney failure 4 years later, with progression of prostate cancer and liver and lung metastases. Serum levels of neuron-specific enolase and pro-gastrinreleasing peptide (tumor markers) were elevated. He underwent re-biopsy of the prostate, and histopathological examination revealed small cell carcinoma. He was initially treated with carboplatin and etoposide therapy. Liver metastases showed partial remission, and serum tumor marker levels were temporarily reduced. However, disease progression was observed after 4 chemotherapy cycles, and he was then treated with an 8-cycle course of amrubicin. Metastases showed shrinkage, and serum tumor marker levels were reduced after 2 chemotherapy cycles. Tumor enlargement recurred after 8 cycles, and the patient is being treated with palliative therapy. Amrubicin therapy may be effective in the treatment of small cell carcinoma of the prostate.
Rights: 許諾条件により本文は2021/05/01に公開
DOI: 10.14989/ActaUrolJap_66_4_121
PubMed ID: 32483946
Appears in Collections:Vol.66 No.4

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