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dc.contributor.authorMorishima, Kenen
dc.contributor.authorOkuda, Ayaen
dc.contributor.authorInoue, Rintaroen
dc.contributor.authorSato, Nobuhiroen
dc.contributor.authorMiyamoto, Yosukeen
dc.contributor.authorUrade, Reikoen
dc.contributor.authorYagi-Utsumi, Mahoen
dc.contributor.authorKato, Koichien
dc.contributor.authorHirano, Rinaen
dc.contributor.authorKujirai, Tomoyaen
dc.contributor.authorKurumizaka, Hitoshien
dc.contributor.authorSugiyama, Masaakien
dc.contributor.alternative守島, 健ja
dc.contributor.alternative奥田, 綾ja
dc.contributor.alternative井上, 倫太郎ja
dc.contributor.alternative佐藤, 信浩ja
dc.contributor.alternative宮本, 洋佑ja
dc.contributor.alternative裏出, 令子ja
dc.contributor.alternative矢木, 真穂ja
dc.contributor.alternative加藤, 晃一ja
dc.contributor.alternative平野, 里奈ja
dc.contributor.alternative鯨井, 智也ja
dc.contributor.alternative胡桃坂, 仁志ja
dc.contributor.alternative杉山, 正明ja
dc.date.accessioned2020-06-09T01:31:01Z-
dc.date.available2020-06-09T01:31:01Z-
dc.date.issued2020-06-08-
dc.identifier.issn2399-3642-
dc.identifier.urihttp://hdl.handle.net/2433/251196-
dc.description溶液中の蛋白質構造を正確に評価するための新規解析法を開発 --構造評価の妨げとなる凝集の影響を実験データから除去--. 京都大学プレスリリース. 2020-06-09.ja
dc.description.abstractCurrently, a sample for small-angle scattering (SAS) is usually highly purified and looks monodispersed: The Guinier plot of its SAS intensity shows a fine straight line. However, it could include the slight aggregates which make the experimental SAS profile different from the monodispersed one. A concerted method with analytical-ultracentrifugation (AUC) and SAS, named as AUC-SAS, offers the precise scattering intensity of a concerned biomacromolecule in solution even with aggregates as well that of a complex under an association-dissociation equilibrium. AUC-SAS overcomes an aggregation problem which has been an obstacle for SAS analysis and, furthermore, has a potential to lead to a structural analysis for a general multi-component system.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Natureen
dc.rights© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectSAXSen
dc.titleIntegral approach to biomacromolecular structure by analytical-ultracentrifugation and small-angle scatteringen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleCommunications Biologyen
dc.identifier.volume3-
dc.relation.doi10.1038/s42003-020-1011-4-
dc.textversionpublisher-
dc.identifier.artnum294-
dc.identifier.pmid32513995-
dc.relation.urlhttps://www.kyoto-u.ac.jp/ja/research-news/2020-06-09-0-
dcterms.accessRightsopen access-
datacite.awardNumber19K16088-
datacite.awardNumber17K07361-
datacite.awardNumber19KK0071-
datacite.awardNumber20K06579-
datacite.awardNumber17K07816-
datacite.awardNumber18H05229-
datacite.awardNumber18H05534-
datacite.awardNumber18H03681-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
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