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j.bbamem.2020.183233.pdf | 16.47 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Matsuzaki, Katsumi | en |
dc.contributor.alternative | 松﨑, 勝巳 | ja |
dc.date.accessioned | 2020-06-12T07:50:41Z | - |
dc.date.available | 2020-06-12T07:50:41Z | - |
dc.date.issued | 2020-08-01 | - |
dc.identifier.issn | 0005-2736 | - |
dc.identifier.issn | 1879-2642 | - |
dc.identifier.uri | http://hdl.handle.net/2433/251422 | - |
dc.description.abstract | It is widely accepted that the abnormal self-association of amyloid β-protein (Aβ) is central to the pathogenesis of Alzheimer's disease, the most common form of dementia. Accumulating evidence, both in vivo and in vitro, suggests that the binding of Aβ to gangliosides, especially monosialoganglioside GM1, plays an important role in the aggregation of Aβ. This review summarizes the molecular details of the binding of Aβ to ganglioside-containing membranes and subsequent structural changes, as revealed by liposomal and cellular studies. Furthermore, mechanisms of cytotoxicity by aggregated Aβ are also discussed. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en |
dc.rights | The full-text file will be made open to the public on 1 August 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Alzheimer's disease | en |
dc.subject | Amyloid β-protein | en |
dc.subject | Gangliosides | en |
dc.subject | Monosialoganglioside GM1 | en |
dc.subject | Amyloid fibrils | en |
dc.subject | Cytotoxicity | en |
dc.title | Aβ–ganglioside interactions in the pathogenesis of Alzheimer's disease | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00564635 | - |
dc.identifier.jtitle | Biochimica et biophysica acta | en |
dc.identifier.volume | 1862 | - |
dc.identifier.issue | 8 | - |
dc.relation.doi | 10.1016/j.bbamem.2020.183233 | - |
dc.textversion | author | - |
dc.identifier.artnum | 183233 | - |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.identifier.pmid | 32142821 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2021-08-01 | - |
dc.identifier.pissn | 0006-3002 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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