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ファイル | 記述 | サイズ | フォーマット | |
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10409238.2020.1758624.pdf | 10.5 MB | Adobe PDF | 見る/開く |
タイトル: | Phosphatidylserine exposure in living cells |
著者: | Shin, Hye Won Takatsu, Hiroyuki |
著者名の別形: | 申, 惠媛 髙津, 宏之 |
キーワード: | Lipid bilayer phosphatidylserine P4-ATPase flippase scramblase |
発行日: | 2020 |
出版者: | Taylor & Francis Group |
誌名: | Critical Reviews in Biochemistry and Molecular Biology |
巻: | 55 |
号: | 2 |
開始ページ: | 166 |
終了ページ: | 178 |
抄録: | P4-ATPases, a subfamily of P-type ATPases, translocate cell membrane phospholipids from the exoplasmic/luminal leaflet to the cytoplasmic leaflet to generate and maintain membrane lipid asymmetry. Exposure of phosphatidylserine (PS) in the exoplasmic leaflet is well known to transduce critical signals for apoptotic cell clearance and platelet coagulation. PS exposure is also involved in many other biological processes, including myoblast and osteoclast fusion, and the immune response. Moreover, mounting evidence suggest that PS exposure is critical for neuronal regeneration and degeneration. In apoptotic cells, PS exposure is induced by irreversible activation of scramblases and inactivation of P4-ATPases. However, how PS is reversibly exposed and restored in viable cells during other biological processes remains poorly understood. In the present review, we discuss the physiological significance of reversible PS exposure in living cells, and the putative roles of flippases, floppases, and scramblases. |
著作権等: | This is an Accepted Manuscript of an article published by Taylor & Francis in 'Critical Reviews in Biochemistry and Molecular Biology' on 2020, available online: https://www.tandfonline.com/10.1080/10409238.2020.1758624 The full-text file will be made open to the public on 14 May 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/252464 |
DOI(出版社版): | 10.1080/10409238.2020.1758624 |
PubMed ID: | 32408772 |
出現コレクション: | 学術雑誌掲載論文等 |
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