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DCフィールド | 値 | 言語 |
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dc.contributor.author | Sato, Masaaki | en |
dc.contributor.author | Mizuta, Kotaro | en |
dc.contributor.author | Islam, Tanvir | en |
dc.contributor.author | Kawano, Masako | en |
dc.contributor.author | Sekine, Yukiko | en |
dc.contributor.author | Takekawa, Takashi | en |
dc.contributor.author | Gomez-Dominguez, Daniel | en |
dc.contributor.author | Schmidt, Alexander | en |
dc.contributor.author | Wolf, Fred | en |
dc.contributor.author | Kim, Karam | en |
dc.contributor.author | Yamakawa, Hiroshi | en |
dc.contributor.author | Ohkura, Masamichi | en |
dc.contributor.author | Lee, Min Goo | en |
dc.contributor.author | Fukai, Tomoki | en |
dc.contributor.author | Nakai, Junichi | en |
dc.contributor.author | Hayashi, Yasunori | en |
dc.contributor.alternative | 佐藤, 正晃 | ja |
dc.contributor.alternative | 水田, 恒太郎 | ja |
dc.contributor.alternative | イスラム, タンビル | ja |
dc.contributor.alternative | 河野, 真子 | ja |
dc.contributor.alternative | 関根, 友紀子 | ja |
dc.contributor.alternative | 竹川, 高志 | ja |
dc.contributor.alternative | ゴメスードミンゲス, ダニエル | ja |
dc.contributor.alternative | シュミット, アレキサンダー | ja |
dc.contributor.alternative | ウォルフ, フレッド | ja |
dc.contributor.alternative | キム, カラム | ja |
dc.contributor.alternative | 山川, 宏 | ja |
dc.contributor.alternative | 大倉, 正道 | ja |
dc.contributor.alternative | リー, ミン・グー | ja |
dc.contributor.alternative | 深井, 朋樹 | ja |
dc.contributor.alternative | 中井, 淳一 | ja |
dc.contributor.alternative | 林, 康紀 | ja |
dc.date.accessioned | 2020-07-09T02:49:23Z | - |
dc.date.available | 2020-07-09T02:49:23Z | - |
dc.date.issued | 2020-07-07 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/2433/252467 | - |
dc.description | 脳内地図を細胞レベルで観察 --自閉症関連遺伝子Shank2はランドマーク情報に必須--. 京都大学プレスリリース. 2020-07-09. | ja |
dc.description.abstract | In the hippocampus, locations associated with salient features are represented by a disproportionately large number of neurons, but the cellular and molecular mechanisms underlying this over-representation remain elusive. Using longitudinal calcium imaging in mice learning to navigate in virtual reality, we find that the over-representation of reward and landmark locations are mediated by persistent and separable subsets of neurons, with distinct time courses of emergence and differing underlying molecular mechanisms. Strikingly, we find that in mice lacking Shank2, an autism spectrum disorder (ASD)-linked gene encoding an excitatory postsynaptic scaffold protein, the learning-induced over-representation of landmarks was absent whereas the over-representation of rewards was substantially increased, as was goal-directed behavior. These findings demonstrate that multiple hippocampal coding processes for unique types of salient features are distinguished by a Shank2-dependent mechanism and suggest that abnormally distorted hippocampal salience mapping may underlie cognitive and behavioral abnormalities in a subset of ASDs. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.subject | two-photon imaging | en |
dc.subject | G-CaMP7 | en |
dc.subject | spatial navigation | en |
dc.subject | cognitive map | en |
dc.subject | spatial learning | en |
dc.subject | memory | en |
dc.subject | Shank | en |
dc.subject | synapses | en |
dc.subject | hippocampal CA1 region | en |
dc.subject | neurodevelopmental disorders | en |
dc.title | Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Reports | en |
dc.identifier.volume | 32 | - |
dc.identifier.issue | 1 | - |
dc.relation.doi | 10.1016/j.celrep.2020.107864 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 107864 | - |
dc.identifier.pmid | 32640229 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2020-07-09-1 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 24700403 | - |
datacite.awardNumber | 25116528 | - |
datacite.awardNumber | 26115530 | - |
datacite.awardNumber | 17H05985 | - |
datacite.awardNumber | 19H04942 | - |
datacite.awardNumber | 20H03550 | - |
datacite.awardNumber | 22110006 | - |
datacite.awardNumber | 16H01292 | - |
datacite.awardNumber | 18H05434 | - |
datacite.awardNumber | 25830023 | - |
datacite.awardNumber | 15H01571 | - |
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datacite.awardNumber | 15H05723 | - |
datacite.awardNumber | 16H06536 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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