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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41467-020-17165-w.pdf | 3.36 MB | Adobe PDF | 見る/開く |
| タイトル: | Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease |
| 著者: | Doi, Daisuke    https://orcid.org/0000-0003-0992-1220 (unconfirmed)Magotani, Hiroaki Kikuchi, Tetsuhiro https://orcid.org/0000-0003-2332-4967 (unconfirmed)Ikeda, Megumi Hiramatsu, Satoe Yoshida, Kenji Amano, Naoki Nomura, Masaki Umekage, Masafumi Morizane, Asuka Takahashi, Jun |
| 著者名の別形: | 土井, 大輔 孫谷, 弘明 菊地, 哲広 池田, 愛 平松, 里恵 吉田, 賢司 天野, 直己 野村, 真樹 梅景, 雅史 森実, 飛鳥 髙橋, 淳 |
| キーワード: | Induced pluripotent stem cells Parkinson's disease Regenerative medicine Stem-cell differentiation |
| 発行日: | 6-Jul-2020 |
| 出版者: | Springer Nature |
| 誌名: | Nature Communications |
| 巻: | 11 |
| 論文番号: | 3369 |
| 抄録: | Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD). The regulatory criteria for the clinical application of these therapies, however, have not been established. Here we show the results of our pre-clinical study, in which we evaluate the safety and efficacy of dopaminergic progenitors (DAPs) derived from a clinical-grade human iPSC line. We confirm the characteristics of DAPs by in vitro analyses. We also verify that the DAP population include no residual undifferentiated iPSCs or early neural stem cells and have no genetic aberration in cancer-related genes. Furthermore, in vivo studies using immunodeficient mice reveal no tumorigenicity or toxicity of the cells. When the DAPs are transplanted into the striatum of 6-OHDA-lesioned rats, the animals show behavioral improvement. Based on these results, we started a clinical trial to treat PD patients in 2018. |
| 記述: | 臨床用iPS細胞を用いたパーキンソン病治療の非臨床研究を実施 --ヒトiPS細胞由来のドパミン神経前駆細胞の安全性と有効性を確認--. 京都大学プレスリリース. 2020-07-20. |
| 著作権等: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/252792 |
| DOI(出版社版): | 10.1038/s41467-020-17165-w |
| PubMed ID: | 32632153 |
| 関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2020-07-20 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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