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タイトル: | Monoamine and genome-wide DNA methylation investigation in behavioral addiction |
著者: | Asaoka, Yui Won, Moojun Morita, Tomonari Ishikawa, Emi Lee, Young-A Goto, Yukiori ![]() ![]() |
著者名の別形: | 浅岡, 由衣 元, 武俊 森田, 智也 石川, 恵己 後藤, 幸織 |
キーワード: | Addiction Epigenetics and behaviour Human behaviour |
発行日: | 16-Jul-2020 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 10 |
論文番号: | 11760 |
抄録: | Behavioral addiction (BA) is characterized by repeated, impulsive and compulsive seeking of specific behaviors, even with consequent negative outcomes. In drug addiction, alterations in biological mechanisms, such as monoamines and epigenetic processes, have been suggested, whereas whether such mechanisms are also altered in BA remains unknown. In this preliminary study with a small sample size, we investigated monoamine concentrations and genome-wide DNA methylation in blood samples from BA patients and control (CT) subjects. Higher dopamine (DA) metabolites and the ratio between DA and its metabolites were observed in the BA group than in the CT group, suggesting increased DA turnover in BA. In the methylation assay, 186 hyper- or hypomethylated CpGs were identified in the BA group compared to the CT group, of which 64 CpGs were further identified to correlate with methylation status in brain tissues with database search. Genes identified with hyper- or hypomethylation were not directly associated with DA transmission, but with cell membrane trafficking and the immune system. Some of the genes were also associated with psychiatric disorders, such as drug addiction, schizophrenia, and autism spectrum disorder. These results suggest that BA may involve alterations in epigenetic regulation of the genes associated with synaptic transmission, including that of monoamines, and neurodevelopment. |
記述: | ⾏動依存症のバイオマーカーを発⾒ --⾏動依存症の⽣理学的特徴の解明--. 京都大学プレスリリース. 2020-07-22. |
著作権等: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/252830 |
DOI(出版社版): | 10.1038/s41598-020-68741-5 |
PubMed ID: | 32678220 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2020-07-22-2 |
出現コレクション: | 学術雑誌掲載論文等 |
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