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タイトル: | Early formation of the Mullerian duct is regulated by sequential actions of BMP/Pax2- and FGF/Lim1 signaling |
著者: | Atsuta, Yuji Takahashi, Yoshiko ![]() ![]() ![]() |
著者名の別形: | 高橋, 淑子 |
キーワード: | Müllerian duct Cell specification Invagination Apical constriction Wolffian duct |
発行日: | 2016 |
出版者: | The Company of Biologists |
誌名: | Development |
巻: | 143 |
号: | 19 |
開始ページ: | 3549 |
終了ページ: | 3559 |
抄録: | The Müllerian duct (MD) and Wolffian duct (WD) are embryonic tubular tissues giving rise to female and male reproductive tracts, respectively. In amniote embryos, both MD and WD emerge in both sexes, but subsequently degenerate in the males and females, respectively. Here, by using MD-specific gene manipulations in chicken embryos, we identify the molecular and cellular mechanisms that link early MD specification to tubular invagination. Early (pre-)specification of MD precursors in the coelomic epithelium requires BMP signaling and its downstream target Pax2 in a WD-independent process. Subsequently, the BMP/Pax2 axis induces Lim1 expression, a hallmark of MD specification, for which FGF/ERK and WD-derived signals are also required. Finally, the sequential actions of the BMP/Pax2 and FGF/Lim1 axes culminate in epithelial invagination to form a tubular structure driven by an apical constriction, where apical accumulation of phospho-myosin light chain is positively regulated by FGF/ERK signaling. Our study delineates mechanisms governing the early formation of the MD, and also serves as a model of how an epithelial cell sheet is transformed to a tubular structure, a process seen in a variety of developmental contexts. |
著作権等: | © 2016. Published by The Company of Biologists Ltd. 許諾条件に基づいて掲載しています。 |
URI: | http://hdl.handle.net/2433/252845 |
DOI(出版社版): | 10.1242/dev.137067 |
PubMed ID: | 27578782 |
出現コレクション: | 学術雑誌掲載論文等 |
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