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09168451.2020.1747974.pdf | 3.86 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Murai, Masatoshi | en |
dc.contributor.alternative | 村井, 正俊 | ja |
dc.date.accessioned | 2020-08-04T07:47:50Z | - |
dc.date.available | 2020-08-04T07:47:50Z | - |
dc.date.issued | 2020-07-02 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | http://hdl.handle.net/2433/253575 | - |
dc.description.abstract | NADH-quinone oxidoreductase (respiratory complex I) is a key player in mitochondrial energy metabolism. The enzyme couples electron transfer from NADH to quinone with the translocation of protons across the membrane, providing a major proton-motive force that drives ATP synthesis. Recently, X-ray crystallography and cryo-electron microscopy provided further insights into the structure and functions of the enzyme. However, little is known about the mechanism of quinone reduction, which is a crucial step in the energy coupling process. A variety of complex I inhibitors targeting the quinone-binding site have been indispensable tools for mechanistic studies on the enzyme. Using biorationally designed inhibitor probes, the author has accumulated a large amount of experimental data characterizing the actions of complex I inhibitors. On the basis of comprehensive interpretations of the data, the author reviews the structural features of the binding pocket of quinone/inhibitors in bovine mitochondrial complex I. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Taylor & Francis Group | en |
dc.rights | This is an Accepted Manuscript of an article published by Taylor & Francis Group in 'Bioscience, Biotechnology, and Biochemistry' on 2020, available online: https://www.tandfonline.com/10.1080/09168451.2020.1747974 | en |
dc.rights | The full-text file will be made open to the public on 07 Apr 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Respiratory complex I | en |
dc.subject | mitochondria | en |
dc.subject | inhibitor | en |
dc.subject | ubiquinone | en |
dc.subject | chemical biology | en |
dc.title | Exploring the binding pocket of quinone/inhibitors in mitochondrial respiratory complex I by chemical biology approaches | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10824164 | - |
dc.identifier.jtitle | Bioscience, Biotechnology, and Biochemistry | en |
dc.identifier.volume | 84 | - |
dc.identifier.spage | 1322 | - |
dc.identifier.epage | 1331 | - |
dc.relation.doi | 10.1080/09168451.2020.1747974 | - |
dc.textversion | author | - |
dc.address | Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University | en |
dc.identifier.pmid | 32264779 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2021-04-07 | - |
dc.identifier.pissn | 0916-8451 | - |
dc.identifier.eissn | 1347-6947 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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