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dc.contributor.authorWatanabe, Mizuki
dc.contributor.authorKanda, Junya
dc.contributor.authorHishizawa, Masakatsu
dc.contributor.authorNishikori, Momoko
dc.contributor.authorKondo, Tadakazu
dc.contributor.authorYamashita, Kouhei
dc.contributor.authorTakaori-Kondo, Akifumi
dc.contributor.alternative渡邊, 瑞希
dc.contributor.alternative諫田, 淳也
dc.contributor.alternative菱澤, 方勝
dc.contributor.alternative錦織, 桃子
dc.contributor.alternative近藤, 忠一
dc.contributor.alternative山下, 浩平
dc.contributor.alternative髙折, 晃史
dc.date.accessioned2020-09-24T06:41:37Z-
dc.date.available2020-09-24T06:41:37Z-
dc.date.issued2020-07
dc.identifier.issn0939-5555
dc.identifier.issn1432-0584
dc.identifier.urihttp://hdl.handle.net/2433/254630-
dc.description.abstractThe number of patients who are administered immunosuppressive agents has been increasing. Accordingly, more patients face higher risks for developing immunodeficiency-associated lymphoproliferative disorders (LPD). Although immunodeficiency-associated LPD are distinct from other lymphoid neoplasms in terms of their immunocompromised backgrounds, little is known about the impact of lymphopenia at diagnosis on survival in patients with these LPD. Seventy-one immunodeficiency-associated LPD in Kyoto University Hospital (post-transplant LPD (PTLD), n = 26; other iatrogenic immunodeficiency-associated LPD, n = 45) were reviewed and analyzed. The median age at diagnosis was 63 years (range, 3–83). Diffuse large B cell lymphoma was the most common subtype (n = 33), followed by Hodgkin lymphoma (n = 12), B cell monomorphic LPD not specified (n = 11), and polymorphic LPD or early-phase diseases (n = 15). The median follow-up period for survivors was 2.5 years and overall survival (OS) and progression-free survival (PFS) at 2.5 years were 75% and 67%, respectively. Multivariate analysis showed that lymphopenia (≤ 800/μL) at diagnosis predicted inferior OS (HR, 3.72; P = 0.043) and PFS (HR, 3.82; P = 0.012). Serum albumin values also strongly affected OS (> 3.18 g/dL vs. ≤ 3.18 g/dL; HR, 0.21; P = 0.010) and PFS (HR, 0.26; P = 0.013). Lymphopenia at diagnosis is suggested to predict inferior OS and PFS in patients with immunodeficiency-associated LPDs. Immunocompromised status might affect disease progression in these distinct lymphoid neoplasms growing under immunocompromised backgrounds.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Annals of Hematology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00277-020-04084-5.
dc.rightsThe full-text file will be made open to the public on 20 May 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
dc.subjectImmunodeficiency-associated lymphoproliferative disorders
dc.subjectPTLD
dc.subjectImmune-suppressive patients
dc.subjectLymphopenia
dc.titleLymphopenia at diagnosis predicts survival of patients with immunodeficiency-associated lymphoproliferative disorders
dc.type.niitypeJournal Article
dc.identifier.jtitleAnnals of Hematology
dc.identifier.volume99
dc.identifier.spage1565
dc.identifier.epage1573
dc.relation.doi10.1007/s00277-020-04084-5
dc.textversionauthor
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University
dc.identifier.pmid32436013
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