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j.stemcr.2020.08.010.pdf | 13.16 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Takeuchi, Akihide | en |
dc.contributor.author | Takahashi, Yuji | en |
dc.contributor.author | Iida, Kei | en |
dc.contributor.author | Hosokawa, Motoyasu | en |
dc.contributor.author | Irie, Koichiro | en |
dc.contributor.author | Ito, Mikako | en |
dc.contributor.author | Brown, J.B. | en |
dc.contributor.author | Ohno, Kinji | en |
dc.contributor.author | Nakashima, Kinichi | en |
dc.contributor.author | Hagiwara, Masatoshi | en |
dc.contributor.alternative | 武内, 章英 | ja |
dc.contributor.alternative | 高橋, 勇次 | ja |
dc.contributor.alternative | 飯田, 慶 | ja |
dc.contributor.alternative | 細川, 元靖 | ja |
dc.contributor.alternative | 入江, 浩一郎 | ja |
dc.contributor.alternative | 伊藤, 美佳子 | ja |
dc.contributor.alternative | 大野, 欽司 | ja |
dc.contributor.alternative | 中島, 欽一 | ja |
dc.contributor.alternative | 萩原, 正敏 | ja |
dc.date.accessioned | 2020-09-28T08:53:03Z | - |
dc.date.available | 2020-09-28T08:53:03Z | - |
dc.date.issued | 2020-10-13 | - |
dc.identifier.issn | 2213-6711 | - |
dc.identifier.uri | http://hdl.handle.net/2433/254692 | - |
dc.description | 神経幹細胞の運命を決める分子を発見 --脳形成機構の解明と脳腫瘍や精神疾患の治療法に期待--. 京都大学プレスリリース. 2020-09-28. | ja |
dc.description.abstract | During brain development, neural stem cells (NSCs) initially produce neurons and change their fate to generate glias. While the regulation of neurogenesis is well characterized, specific markers for glial precursor cells (GPCs) and the master regulators for gliogenesis remain unidentified. Accumulating evidence suggests that RNA-binding proteins (RBPs) have significant roles in neuronal development and function, as they comprehensively regulate the expression of target genes in a cell-type-specific manner. We systematically investigated the expression profiles of 1, 436 murine RBPs in the developing mouse brain and identified quaking (Qk) as a marker of the putative GPC population. Functional analysis of the NSC-specific Qk-null mutant mouse revealed the key role of Qk in astrocyte and oligodendrocyte generation and differentiation from NSCs. Mechanistically, Qk upregulates gliogenic genes via quaking response elements in their 3′ untranslated regions. These results provide crucial directions for identifying GPCs and deciphering the regulatory mechanisms of gliogenesis from NSCs. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.subject | RNA-binding protein | en |
dc.subject | quaking/Qk | en |
dc.subject | neural stem cells/NSCs | en |
dc.subject | glial precursor cells/GPCs | en |
dc.subject | gliogenesis | en |
dc.subject | mRNA stabilization | en |
dc.subject | 3′ untranslated region | en |
dc.subject | regulon | en |
dc.subject | endocytosis | en |
dc.subject | RNA-seq | en |
dc.title | Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Stem Cell Reports | en |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 883 | - |
dc.identifier.epage | 897 | - |
dc.relation.doi | 10.1016/j.stemcr.2020.08.010 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 32976762 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2020-09-28-1 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 19500269 | - |
datacite.awardNumber | 25500288 | - |
datacite.awardNumber | 21249013 | - |
datacite.awardNumber | 15H05721 | - |
datacite.awardNumber | 19K06907 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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