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Title: Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect
Authors: Baba, Kiichiro
Nomura, Motoo
Ohashi, Shinya  kyouindb  KAKEN_id
Hiratsuka, Takuya
Nakai, Yukie
Saito, Tomoki
Kondo, Yuki
Fukuyama, Keita
Kikuchi, Osamu
Yamada, Atsushi  kyouindb  KAKEN_id
Matsubara, Junichi
Hirohashi, Kenshiro
Mitani, Yosuke
Mizumoto, Ayaka
Muto, Manabu  kyouindb  KAKEN_id
Author's alias: 馬場, 希一郎
武藤, 学
Keywords: Abscopal effect
tumor-specific CD8+ T cells
anti-PD1 antibody
radiation dose
irradiated-tumor volume
Issue Date: 1-Feb-2020
Publisher: e-Century Publishing Corporation
Journal title: American journal of cancer research
Volume: 10
Issue: 2
Start page: 440
End page: 453
Abstract: Radiotherapy (RT) is the primary treatment for cancer. Ionizing radiation from RT induces tumor damage at the irradiated site, and, although clinically infrequent, may cause regression of tumors distant from the irradiated site-a phenomenon known as the abscopal effect. Recently, the abscopal effect has been related to prolongation of overall survival time in cancer patients, though the factors that influence the abscopal effect are not well understood. The aim of this study is to clarify the factors influencing on abscopal effect. Here, we established a mouse model in which we induced the abscopal effect. We injected MC38 (mouse colon adenocarcinoma) cells subcutaneously into C57BL/6 mice at two sites. Only one tumor was irradiated and the sizes of both tumors were measured over time. The non-irradiated-site tumor showed regression, demonstrating the abscopal effect. This effect was enhanced by an increase in the irradiated-tumor volume and by administration of anti-PD1 antibody. When the abscopal effect was induced by a combination of RT and anti-PD1 antibody, it was also influenced by radiation dose and irradiated-tumor volume. These phenomena were also verified in other cell line, B16F10 cells (mouse melanoma cells). These findings provide further evidence of the mechanism for, and factors that influence, the abscopal effect in RT.
Rights: Once the paper is published, the copyright will be released by the publisher under the “Creative Commons Attribution Noncommercial License”, enabling the unrestricted non-commercial use, distribution, and reproduction of the published article in any medium, provided that the original work is properly cited.
PubMed ID: 32195019
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