ダウンロード数: 158
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
pnas.1919253117.pdf | 1.17 MB | Adobe PDF | 見る/開く |
タイトル: | Forelimb force direction and magnitude independently controlled by spinal modules in the macaque |
著者: | Yaron, Amit Kowalski, David Yaguchi, Hiroaki Takei, Tomohiko Seki, Kazuhiko |
著者名の別形: | 矢口, 博彬 武井, 智彦 関, 和彦 |
キーワード: | monkey spinal cord force field summation modularity |
発行日: | 3-Nov-2020 |
出版者: | National Academy of Sciences |
誌名: | Proceedings of the National Academy of Sciences |
巻: | 117 |
号: | 44 |
開始ページ: | 27655 |
終了ページ: | 27666 |
抄録: | Modular organization of the spinal motor system is thought to reduce the cognitive complexity of simultaneously controlling the large number of muscles and joints in the human body. Although modular organization has been confirmed in the hindlimb control system of several animal species, it has yet to be established in the forelimb motor system or in primates. Expanding upon experiments originally performed in the frog lumbar spinal cord, we examined whether costimulation of two sites in the macaque monkey cervical spinal cord results in motor activity that is a simple linear sum of the responses evoked by stimulating each site individually. Similar to previous observations in the frog and rodent hindlimb, our analysis revealed that in most cases (77% of all pairs) the directions of the force fields elicited by costimulation were highly similar to those predicted by the simple linear sum of those elicited by stimulating each site individually. A comparable simple summation of electromyography (EMG) output, especially in the proximal muscles, suggested that this linear summation of force field direction was produced by a spinal neural mechanism whereby the forelimb motor output recruited by costimulation was also summed linearly. We further found that the force field magnitudes exhibited supralinear (amplified) summation, which was also observed in the EMG output of distal forelimb muscles, implying a novel feature of primate forelimb control. Overall, our observations support the idea that complex movements in the primate forelimb control system are made possible by flexibly combined spinal motor modules. |
記述: | 腕の自由自在な動きをつくりだす多機能な神経細胞群の発見 --運動の方向と大きさを同時にコントロールする神経メカニズムの解明--. 京都大学プレスリリース. 2020-10-14. Primates aren't quite frogs. 京都大学プレスリリース. 2020-10-19. |
著作権等: | © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). |
URI: | http://hdl.handle.net/2433/255585 |
DOI(出版社版): | 10.1073/pnas.1919253117 |
PubMed ID: | 33060294 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2020-10-14-1 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。