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Title: Longitudinal association between mental health and future antibiotic prescriptions in healthy adults: Results from the LOHAS
Authors: Tochitani, Kentaro
Yamamoto, Shungo
Kamitani, Tsukasa  kyouindb  KAKEN_id  orcid (unconfirmed)
Yamazaki, Hajime  kyouindb  KAKEN_id  orcid (unconfirmed)
Fukuhara, Shunichi
Yamamoto, Yosuke  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 栃谷, 健太郎
山本, 舜悟
紙谷, 司
山崎, 大
福原, 俊一
山本, 洋介
Issue Date: 5-Oct-2020
Publisher: Public Library of Science (PLoS)
Journal title: PLOS ONE
Volume: 15
Issue: 10
Thesis number: e0240236
Abstract: Objectives: To investigate the association of mental health and subjective physical functioning with future antibiotic prescriptions. Design: Prospective cohort study. Setting: A rural town in Japan. Participants: Participants who completed the baseline survey (2008-2010) of the Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study (LOHAS) were recruited. Participants were limited to those without comorbidities according to the Charlson comorbidity index. Participants using antibiotics at baseline were excluded. Mental health and physical functioning were assessed using the Mental Health and Physical Functioning domains of the Short-Form 12 Health Survey, and depressive symptoms were assessed using the Mental Health Inventories at baseline. Main outcome measures: The main outcome was antibiotic prescriptions found in claims data during 1 year after the baseline survey. Results: A total of 967 participants were included in the analysis, and 151 (15.6%) participants with at least one missing variable for the confounding factors were excluded, leaving 816 participants for the primary analysis. Among the 816 participants, 65 (8.0%) were newly prescribed at least one antibiotic during the 1-year follow-up period. The most frequently prescribed antibiotics were third-generation cephalosporins (44 prescriptions; 35.5%), macrolides (28 prescriptions; 22.6%), and quinolones (23 prescriptions; 18.6%). A multivariable logistic regression analysis showed an association between higher mental health scores and future antibiotic prescriptions (adjusted odds ratio [AOR], 1.40 per 1 standard deviation [SD] increase; 95% confidence interval [CI], 1.03-1.90), whereas no significant relationship was observed between Physical Functioning scores and future antibiotic prescriptions (AOR, 0.95 per 1 SD increase; 95% CI, 0.75-1.22). During the secondary analysis, adults with depressive symptoms were less likely to be prescribed antibiotics (AOR, 0.27; 95% CI, 0.11-0.70). Conclusions: Better mental health was associated with increased future antibiotic prescriptions for healthy community-dwelling Japanese adults, suggesting that mentally healthier adults could be a target population for reducing antimicrobial use.
Rights: © 2020 Tochitani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0240236
PubMed ID: 33017453
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