膀胱Squamous cell papillomaの1例

Abstract

We report a case of squamous cell papilloma of the urinary bladder, which is an extremely rare disease with only 15 cases reported in the Japanese and English literature. The case was in a 76-year-old woman. She was referred to the department of urology because multifocal tumors of the urinary bladder were found by computed tomographic scan during an examination for acute enteritis. Cystoscopy showed a nonpapillary flat tumor with whitish plaque on the left posterior wall, measuring 3 cm. Urinalysis and urine cytology revealed no abnormalities. Transurethral resection was performed. Histology revealed a papillary noninvasive squamous cell tumor with extensive keratinization on its surface. There were no nuclear atypia or evidence of koilocytotic change. Immunohistochemically, the tumor cells were negative for both p16 and p53. Based on the pathological findings, the tumor was diagnosed as squamous cell papilloma. The tumor recurred three month after the operation and she is being followed with no change observed for two and a half years.