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dc.contributor.author | Kameo, Yoshitaka | en |
dc.contributor.author | Sakano, Nobuaki | en |
dc.contributor.author | Adachi, Taiji | en |
dc.contributor.alternative | 亀尾, 佳貴 | ja |
dc.contributor.alternative | 安達, 泰治 | ja |
dc.date.accessioned | 2021-01-15T07:49:29Z | - |
dc.date.available | 2021-01-15T07:49:29Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2352-1872 | - |
dc.identifier.uri | http://hdl.handle.net/2433/261031 | - |
dc.description.abstract | Microstructures of cortical and cancellous bones are altered continually by load-adaptive remodeling; in addition, their cellular mechanisms are similar despite the remarkably different porosities. The cortico-cancellous transitional zone is a site of vigorous remodeling, and intracortical remodeling cavitates the inner cortex to promote its trabecularization, which is considered the main cause of bone loss because of aging. Therefore, to prevent and treat age-related cortical bone loss effectively, it is indispensable to gain an integrated understanding of the cortical to the cancellous bone transformation via remodeling. We propose a novel theoretical concept to account for the transformation of dense cortical bone to porous cancellous bone. We develop a mathematical model of cortical and cancellous bone remodeling based on the concept that bone porosity is determined by the balance between the load-bearing function of mineralized bone and the material-transporting function of bone marrow. Remodeling simulations using this mathematical model enable the reproduction of the microstructures of cortical and cancellous bones simultaneously. Furthermore, current remodeling simulations have the potential to replicate cortical-to-cancellous bone transformation based on changes in the local balance between bone formation and resorption. We anticipate that the proposed mathematical model of cortical and cancellous bone remodeling will contribute to highlighting the essential features of cortical bone loss due to trabecularization of the cortex and help predict its spatial and temporal behavior during aging. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/) | en |
dc.subject | Cortical bone | en |
dc.subject | Cancellous bone | en |
dc.subject | Cortical-to-cancellous bone transformation | en |
dc.subject | Remodeling simulation | en |
dc.subject | Mathematical model | en |
dc.title | Theoretical concept of cortical to cancellous bone transformation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Bone Reports | en |
dc.identifier.volume | 12 | - |
dc.relation.doi | 10.1016/j.bonr.2020.100260 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 100260 | - |
dc.address | Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University・Department of Micro Engineering, Graduate School of Engineering, Kyoto University・Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University | en |
dc.address | Department of Micro Engineering, Graduate School of Engineering, Kyoto University | en |
dc.address | Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University・Department of Micro Engineering, Graduate School of Engineering, Kyoto University・Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University | en |
dc.identifier.pmid | 32551336 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 19K04074 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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