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Title: Association between Body Mass Index and Prognosis of Patients Hospitalized With Heart Failure
Authors: Seko, Yuta
Kato, Takao  kyouindb  KAKEN_id  orcid (unconfirmed)
Morimoto, Takeshi
Yaku, Hidenori
Inuzuka, Yasutaka
Tamaki, Yodo
Ozasa, Neiko
Shiba, Masayuki
Yamamoto, Erika
Yoshikawa, Yusuke
Yamashita, Yugo  kyouindb  KAKEN_id
Kitai, Takeshi
Taniguchi, Ryoji
Iguchi, Moritake
Nagao, Kazuya
Kawai, Takafumi
Komasa, Akihiro
Nishikawa, Ryusuke
Kawase, Yuichi
Morinaga, Takashi
Toyofuku, Mamoru
Furukawa, Yutaka
Ando, Kenji
Kadota, Kazushige
Sato, Yukihito
Kuwahara, Koichiro
Kimura, Takeshi
Author's alias: 加藤, 貴雄
小笹, 寧子
山本, 絵里香
山下, 侑吾
木村, 剛
Issue Date: Oct-2020
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 10
Thesis number: 16663
Abstract: The prognostic implications of very low body mass index (BMI) values remain unclear in patients with acute decompensated heart failure (ADHF). This study aimed to investigate the prognostic impact of BMI classification based on the World Health Organization criteria in patients with ADHF. Among 3509 patients with ADHF and available BMI data at discharge in 19 participating hospitals in Japan between October 2014 and March 2016, the study population was divided into five groups; (1) Severely underweight: BMI < 16 kg/m², (2) Underweight: BMI ≥ 16 kg/m² and < 18.5 kg/m², (3) Normal weight: BMI ≥ 18.5 kg/m² and < 25 kg/m², (4) Overweight: BMI ≥ 25 kg/m² and < 30 kg/m² (5) Obese: BMI ≥ 30 kg/m². The primary outcome measure was all-cause death. The median follow-up duration was 471 days, with 96.4% follow up at 1-year. The cumulative 1-year incidence of all-cause death was higher in underweight groups, and lower in overweight groups (Severely underweight: 36.3%, Underweight: 23.9%, Normal weight: 14.4%, Overweight: 7.9%, and Obese: 9.0%, P < 0.001). After adjusting confounders, the excess mortality risk remained significant in the severely underweight group (HR, 2.32; 95%CI, 1.83–2.94; P < 0.001), and in the underweight group (HR, 1.31; 95%CI, 1.08–1.59; P = 0.005) relative to the normal weight group, while the lower mortality risk was no longer significant in the overweight group (HR, 0.82; 95%CI, 0.62–1.10; P = 0.18) and in the obese group (HR, 1.09; 95%CI, 0.65–1.85; P = 0.74). Very low BMI was associated with a higher risk for one-year mortality after discharge in patients with ADHF.
Rights: © The Author(s) 2020 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
DOI(Published Version): 10.1038/s41598-020-73640-w
PubMed ID: 33028856
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