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s41467-021-21107-5.pdf | 4.16 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Horie, Takahiro | - |
dc.contributor.author | Nakao, Tetsushi | - |
dc.contributor.author | Miyasaka, Yui | - |
dc.contributor.author | Nishino, Tomohiro | - |
dc.contributor.author | Matsumura, Shigenobu | - |
dc.contributor.author | Nakazeki, Fumiko | - |
dc.contributor.author | Ide, Yuya | - |
dc.contributor.author | Kimura, Masahiro | - |
dc.contributor.author | Tsuji, Shuhei | - |
dc.contributor.author | Rodriguez, Randolph Ruiz | - |
dc.contributor.author | Watanabe, Toshimitsu | - |
dc.contributor.author | Yamasaki, Tomohiro | - |
dc.contributor.author | Xu, Sijia | - |
dc.contributor.author | Otani, Chiharu | - |
dc.contributor.author | Miyagawa, Sawa | - |
dc.contributor.author | Matsushita, Kazuki | - |
dc.contributor.author | Sowa, Naoya | - |
dc.contributor.author | Omori, Aoi | - |
dc.contributor.author | Tanaka, Jin | - |
dc.contributor.author | Nishimura, Chika | - |
dc.contributor.author | Nishiga, Masataka | - |
dc.contributor.author | Kuwabara, Yasuhide | - |
dc.contributor.author | Baba, Osamu | - |
dc.contributor.author | Watanabe, Shin | - |
dc.contributor.author | Nishi, Hitoo | - |
dc.contributor.author | Nakashima, Yasuhiro | - |
dc.contributor.author | Picciotto, Marina R. | - |
dc.contributor.author | Inoue, Haruhisa | - |
dc.contributor.author | Watanabe, Dai | - |
dc.contributor.author | Nakamura, Kazuhiro | - |
dc.contributor.author | Sasaki, Tsutomu | - |
dc.contributor.author | Kimura, Takeshi | - |
dc.contributor.author | Ono, Koh | - |
dc.contributor.alternative | 堀江, 貴裕 | - |
dc.contributor.alternative | 中尾, 哲史 | - |
dc.contributor.alternative | 宮阪, 由依 | - |
dc.contributor.alternative | 西野, 共達 | - |
dc.contributor.alternative | 松村, 成暢 | - |
dc.contributor.alternative | 中関, 典子 | - |
dc.contributor.alternative | 井手, 裕也 | - |
dc.contributor.alternative | 木村, 昌弘 | - |
dc.contributor.alternative | 辻, 修平 | - |
dc.contributor.alternative | 渡邉, 利光 | - |
dc.contributor.alternative | 山﨑, 智弘 | - |
dc.contributor.alternative | 徐, 斯佳 | - |
dc.contributor.alternative | 大谷, 千春 | - |
dc.contributor.alternative | 宮川, 紗和 | - |
dc.contributor.alternative | 松下, 和揮 | - |
dc.contributor.alternative | 曽和, 尚也 | - |
dc.contributor.alternative | 大森, 碧 | - |
dc.contributor.alternative | 田中, 仁 | - |
dc.contributor.alternative | 西村, 知華 | - |
dc.contributor.alternative | 西賀, 雅隆 | - |
dc.contributor.alternative | 桑原, 康秀 | - |
dc.contributor.alternative | 馬場, 理 | - |
dc.contributor.alternative | 渡邉, 真 | - |
dc.contributor.alternative | 西, 仁勇 | - |
dc.contributor.alternative | 中島, 康弘 | - |
dc.contributor.alternative | 井上, 治久 | - |
dc.contributor.alternative | 渡邉, 大 | - |
dc.contributor.alternative | 中村, 和弘 | - |
dc.contributor.alternative | 佐々木, 努 | - |
dc.contributor.alternative | 木村, 剛 | - |
dc.contributor.alternative | 尾野, 亘 | - |
dc.date.accessioned | 2021-02-18T00:19:40Z | - |
dc.date.available | 2021-02-18T00:19:40Z | - |
dc.date.issued | 2021-02-16 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2433/261710 | - |
dc.description | 褐色脂肪細胞の燃焼を促す新たなメカニズムを解明 --体の熱産生にマイクロRNA-33が関与--. 京都大学プレスリリース. 2021-02-17. | - |
dc.description.abstract | Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33−/− mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33f/f dopamine-β-hydroxylase (DBH)-Cre mice indicates the importance of miR-33 in Dbh-positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA)A receptor subunit genes such as Gabrb2 and Gabra4. Knock-down of these genes in Dbh-positive neurons rescues the impaired cold-induced thermogenesis in miR-33f/f DBH-Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.rights | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | - |
dc.subject | Experimental models of disease | - |
dc.subject | Metabolic disorders | - |
dc.title | microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature Communications | en |
dc.identifier.volume | 12 | - |
dc.relation.doi | 10.1038/s41467-021-21107-5 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 843 | - |
dc.identifier.pmid | 33594062 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2021-02-17-1 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 17K09860 | - |
datacite.awardNumber | 20K08904 | - |
datacite.awardNumber | 1605297 | - |
datacite.awardNumber | 17H04177 | - |
datacite.awardNumber | 17H05599 | - |
datacite.awardNumber | 20H03675 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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