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Title: Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis
Authors: Murakami, Isao
Murakami, Kosaku  kyouindb  KAKEN_id  orcid (unconfirmed)
Hashimoto, Motomu  kyouindb  KAKEN_id
Tanaka, Masao  kyouindb  KAKEN_id  orcid (unconfirmed)
Ito, Hiromu
Fujii, Takao
Torii, Mie  kyouindb  KAKEN_id
Ikeda, Kaori  kyouindb  KAKEN_id  orcid (unconfirmed)
Kuwabara, Akiko
Tanaka, Kiyoshi
Yoshida, Akiko
Akizuki, Shuji  kyouindb  KAKEN_id
Nakashima, Ran
Yoshifuji, Hajime  kyouindb  KAKEN_id  orcid (unconfirmed)
Ohmura, Koichiro
Usui, Takashi
Morita, Satoshi
Mimori, Tsuneyo
Author's alias: 村上, 孝作
池田, 香織
森田, 智視
Issue Date: 13-Feb-2020
Publisher: Public Library of Science (PLoS)
Journal title: PLoS ONE
Volume: 15
Issue: 2
Abstract: Objective: To clarify the relationship between dietary habit and disease activity of rheumatoid arthritis (RA). Methods: This study enrolled RA patients who met the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort in 2015. 22-item food frequency questionnaire (FFQ) was taken for the measurement of dietary habit in a single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management Alliance: KURAMA) in 2015. The disease activities of RA using the Disease Activity Score calculated based on the erythrocyte sedimentation rate (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment Questionnaire (HAQ), and serum matrix metalloproteinase-3 (MMP-3) level, the use of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid factor, anti-cyclic citrullinated antibody, and body mass index were also examined. All of them were combined and statistically analyzed. Results: 441 RA patients (81% women; mean age 65 years; mean disease duration 15 years) were enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed that intake frequency of vegetables had a statistically significant negative correlation with disease activity markers, such as DAS28-ESR (ρ = −0.11, p<0.01), Simplified Disease Activity Index (SDAI) (ρ = −0.16, p<0.001), matrix metalloproteinase-3 (MMP-3) (ρ = −0.21, p<0.0001), and Health Assessment Questionnaire (HAQ) (ρ = −0.13, p<0.01). Factor analysis with varimax rotation was done to simplify the relevance of disease activity to various food items. 22 foods were categorized into five dietary patterns: “seafoods”, “vegetables/fruits”, “meats/fried foods”, “snacks”, and “processed foods”. The multivariate analysis adjusted for clinically significant confounders showed that “seafoods” had statistically significant negative correlations with DAS28-ESR (β = −0.15, p<0.01), SDAI (β = −0.18, p<0.001), MMP-3 (β = −0.15, p<0.01), and HAQ (β = −0.24, p<0.0001). “Vegetables/fruits” had statistically significant negative correlations with SDAI (β = −0.11 p<0.05), MMP-3 (β = −0.12, p<0.01), and HAQ (β = −0.11, p<0.05) Conclusions: These results suggest that high intake frequency of vegetables/fruits and/or seafoods might correlate with low disease activity.
Rights: © 2020 Murakami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0228852
PubMed ID: 32053642
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