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dc.contributor.author | Itoigawa, Akihiro | en |
dc.contributor.author | Fierro, Fabrizio | en |
dc.contributor.author | Chaney, E, Morgan | en |
dc.contributor.author | Lauterbur, Elise, M | en |
dc.contributor.author | Hayakawa, Takashi | en |
dc.contributor.author | Tosi, J, Anthony | en |
dc.contributor.author | Niv, Y, Masha | en |
dc.contributor.author | Imai, Hiroo | en |
dc.contributor.alternative | 糸井川, 壮大 | ja |
dc.contributor.alternative | 早川, 卓志 | ja |
dc.contributor.alternative | 今井, 啓雄 | ja |
dc.date.accessioned | 2021-04-30T08:49:43Z | - |
dc.date.available | 2021-04-30T08:49:43Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | http://hdl.handle.net/2433/262712 | - |
dc.description | 竹食サル類の苦味感覚の進化を解明 --竹が先か苦味が先か--. 京都大学プレスリリース. 2021-04-16. | ja |
dc.description.abstract | Bitter taste facilitates the detection of potentially harmful substances and is perceived via bitter taste receptors (TAS2Rs) expressed on the tongue and oral cavity in vertebrates. In primates, TAS2R16 specifically recognizes β-glucosides, which are important in cyanogenic plants' use of cyanide as a feeding deterrent. In this study, we performed cell-based functional assays for investigating the sensitivity of TAS2R16 to β-glucosides in three species of bamboo lemurs (Prolemur simus, Hapalemur aureus and H. griseus), which primarily consume high-cyanide bamboo. TAS2R16 receptors from bamboo lemurs had lower sensitivity to β-glucosides, including cyanogenic glucosides, than that of the closely related ring-tailed lemur (Lemur catta). Ancestral reconstructions of TAS2R16 for the bamboo-lemur last common ancestor (LCA) and that of the Hapalemur LCA showed an intermediate sensitivity to β-glucosides between that of the ring-tailed lemurs and bamboo lemurs. Mutagenetic analyses revealed that P. simus and H. griseus had separate species-specific substitutions that led to reduced sensitivity. These results indicate that low sensitivity to β-glucosides at the cellular level-a potentially adaptive trait for feeding on cyanogenic bamboo-evolved independently after the Prolemur-Hapalemur split in each species. | en |
dc.language.iso | eng | - |
dc.publisher | Royal Society | en |
dc.rights | © 2021 The Authors. | en |
dc.rights | Published by the Royal Society under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, provided the original author and source are credited. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | bitter taste receptor | en |
dc.subject | molecular adaptation | en |
dc.subject | cyanide | en |
dc.subject | homoplasy | en |
dc.subject | lemur | en |
dc.subject | glucosides | en |
dc.title | Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16? | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Proceedings of the Royal Society B: Biological Sciences | en |
dc.identifier.volume | 288 | - |
dc.identifier.issue | 1948 | - |
dc.relation.doi | 10.1098/rspb.2021.0346 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 20210346 | - |
dc.address | Molecular Biology Section, Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University; Japan Society for the Promotion of Science | en |
dc.address | The Institute of Biochemistry, Food Science and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem | en |
dc.address | Department of Anthropology, Kent State University | en |
dc.address | Department of Ecology and Evolutionary Biology, The University of Arizona | en |
dc.address | Faculty of Environmental Earth Science, Hokkaido University; Japan Monkey Centre | en |
dc.address | Department of Anthropology, Kent State University | en |
dc.address | The Institute of Biochemistry, Food Science and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem | en |
dc.address | Molecular Biology Section, Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University | en |
dc.identifier.pmid | 33849315 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2021-04-16-1 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 18J22288 | - |
datacite.awardNumber | 16K18630 | - |
datacite.awardNumber | 18H04005 | - |
datacite.awardNumber | 19K21586 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18J22288/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K18630/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18H04005/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K21586/ | - |
dc.identifier.pissn | 0962-8452 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | ジェントルキツネザルのタケ食適応過程における味覚受容体進化機構の解明 | ja |
jpcoar.awardTitle | 霊長類におけるゲノム・メタゲノム相関とその進化的意義の解明 | ja |
jpcoar.awardTitle | 新世界と旧世界の対比による霊長類感覚生態ゲノム学の確立 | ja |
jpcoar.awardTitle | 味覚機能の未病状態検知と味蕾移植の可能性探索 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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