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タイトル: | 腹腔鏡ならびにロボット支援前立腺全摘除術の拡大リンパ節郭清術におけるpN1症例の術後再発リスク因子 |
その他のタイトル: | Risk Factors for Recurrence in Patients with Pathological Lymph Node-Positive Prostate Cancer after Extended Lymph Node Dissection in Laparoscopic and Robotic-Assisted Radical Prostatectomy |
著者: | 山口, 立樹 村田, 詩織 国分, 英利 牧田, 哲幸 阿部, 陽平 久保田, 聖史 堤, 尚史 杉野, 善雄 宇都宮, 紀明 岡田, 卓也 井上, 幸治 川喜田, 睦司 |
著者名の別形: | Yamaguchi, Ritsuki Murata, Shiori Kokubun, Hidetoshi Makita, Noriyuki Abe, Yohei Kubota, Masashi Tsutsumi, Naofumi Sugino, Yoshio Utsunomiya, Noriaki Okada, Takuya Inoue, Koji Kawakita, Mutushi |
キーワード: | Prostate cancer Extended lymph node dissection pN1 Recurrence Riskfactors |
発行日: | 31-Mar-2021 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 67 |
号: | 3 |
開始ページ: | 83 |
終了ページ: | 90 |
抄録: | From April 2007 to April 2018, we performed lymph node dissection in 305 cases of laparoscopic radical prostatectomy and 202 cases of robot-assisted radical prostatectomy at our hospital, and there were 68 cases with positive lymph node metastasis (pN1). Of these 68 cases, we examined retrospectively 62 cases in which extended lymph node dissection (ELND) was performed. The median number of removed lymph nodes was 25 (interquartile range [IQR] ; 18-34) and the median number of metastatic lymph nodes was 1 (IQR ; 1-3). Postoperative prostate-specific antigen (PSA) recurrence was observed in 40 of the 62 patients. The median time to PSA recurrence was 24 months. After univariate analysis, PSA at initial diagnosis (iPSA) of 10 ng/ml or more, pathological Gleason score (pGS) of 8 or more, total number of lymph node metastases of 2 or more, and positive surgical margin (RM+) were found to be riskfactors of PSA recurrence. In multivariate analysis, iPSA of 10 ng/ml or more, pGS of 8 or more and RM+ were independent riskfactors of PSA recurrence (p<0.05). In the cases without riskfactors such as iPSA≥10, pGS≥8, and RM+, immediate postoperative adjuvant therapy may be avoided even with pN1. |
著作権等: | 許諾条件により本文は2022-04-01に公開 |
DOI: | 10.14989/ActaUrolJap_67_3_83 |
URI: | http://hdl.handle.net/2433/262756 |
PubMed ID: | 33957027 |
出現コレクション: | Vol.67 No.3 |
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