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j.ultrasmedbio.2021.02.009.pdf725.94 kBAdobe PDF見る/開く
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dc.contributor.authorWang, Tianshuen
dc.contributor.authorIto, Akiraen
dc.contributor.authorXu, Shixuanen
dc.contributor.authorKawai, Hidekien
dc.contributor.authorKuroki, Hiroshien
dc.contributor.authorAoyama, Tomokien
dc.contributor.alternative伊藤, 明良ja
dc.contributor.alternative河合, 秀樹ja
dc.contributor.alternative黒木, 裕士ja
dc.contributor.alternative青山, 朋樹ja
dc.date.accessioned2021-06-16T07:04:30Z-
dc.date.available2021-06-16T07:04:30Z-
dc.date.issued2021-06-
dc.identifier.urihttp://hdl.handle.net/2433/263336-
dc.description.abstractThe aim of this study was to determine that low-intensity pulsed ultrasound (LIPUS) at an intensity of 140 mW/cm² promotes functional and histologic improvements in sciatic nerve crush injury in a rat model and to investigate changes over time in relevant growth factors and receptors, exploring the mechanism of LIPUS in the recovery process after injury. Toe angle in the toe-off phase, regenerative axonal length, myelinated nerve fiber density, diameter of myelinated nerve fiber, axon diameter and myelin sheath thickness were significantly higher in the LIPUS group than in the sham group. Gene and protein expression of brain-derived neurotrophic factor (BDNF) was upregulated in the LIPUS group. In conclusion, LIPUS contributed to rapid functional and histologic improvement and upregulated BDNF expression after sciatic nerve crush injury in rats.en
dc.language.isoeng-
dc.publisherElsevier BVen
dc.rights© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rightsThe full-text file will be made open to the public on 1 June 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。en
dc.subjectLow-intensity pulsed ultrasounden
dc.subjectPeripheral nerve regenerationen
dc.subjectFunctional improvementen
dc.subjectChangesover timeen
dc.subjectBrain-derived neurotrophic factoren
dc.titleLow-Intensity Pulsed Ultrasound Prompts Both Functional and Histologic Improvements While Upregulating the Brain-Derived Neurotrophic Factor Expression after Sciatic Crush Injury in Ratsen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleUltrasound in medicine & biologyen
dc.identifier.volume47-
dc.identifier.issue6-
dc.identifier.spage1586-
dc.identifier.epage1595-
dc.relation.doi10.1016/j.ultrasmedbio.2021.02.009-
dc.textversionauthor-
dc.identifier.pmid33745752-
dcterms.accessRightsopen access-
datacite.date.available2022-06-01-
dc.identifier.pissn0301-5629-
出現コレクション:学術雑誌掲載論文等

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