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Title: Quantitative and qualitative evaluation of sequential PET/MRI using a newly developed mobile PET system for brain imaging
Authors: Suzuki, Mizue
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1982-3168 (unconfirmed)
Okada, Tomohisa
Hinoda, Takuya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8111-0153 (unconfirmed)
Nakamoto, Ryusuke
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-4626-4645 (unconfirmed)
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Togashi, Kaori
Nakamoto, Yuji
Author's alias: 伏見, 育崇
岡田, 知久
日野田, 卓也
中本, 隆介
荒川, 芳輝
澤本, 伸克
中本, 裕士
Keywords: Mobile PET
PET/MRI
PET/CT
Issue Date: Jul-2021
Publisher: Springer Nature
Journal title: Japanese Journal of Radiology
Volume: 39
Issue: 7
Start page: 669
End page: 680
Abstract: [Purpose]To evaluate the clinical feasibility of a newly developed mobile PET system with MR-compatibility (flexible PET; fxPET), compared with conventional PET (cPET)/CT for brain imaging.[Methods]Twenty-one patients underwent cPET/CT with subsequent fxPET/MRI using 18F-FDG. As qualitative evaluation, we visually rated image quality of MR and PET images using a four-point scoring system. We evaluated overall image quality for MR, while we evaluated overall image quality, sharpness and lesion contrast. As quantitative evaluation, we compared registration accuracy between two modalities [(fxPET and MRI) and (cPET and CT)] measuring spatial coordinates. We also examined the accuracy of regional 18F-FDG uptake.[Results]All acquired images were of diagnostic quality and the number of detected lesions did not differ significantly between fxPET/MR and cPET/CT. Mean misregistration was significantly larger with fxPET/MRI than with cPET/CT. SUVmax and SUVmean for fxPET and cPET showed high correlations in the lesions (R = 0.84, 0.79; P < 0.001, P = 0.002, respectively). In normal structures, we also showed high correlations of SUVmax (R = 0.85, 0.87; P < 0.001, P < 0.001, respectively) and SUVmean (R = 0.83, 0.87; P < 0.001, P < 0.001, respectively) in bilateral caudate nuclei and a moderate correlation of SUVmax (R = 0.65) and SUVmean (R = 0.63) in vermis.[Conclusions]The fxPET/MRI system showed image quality within the diagnostic range, registration accuracy below 3 mm and regional 18F-FDG uptake highly correlated with that of cPET/CT.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Quantitative and qualitative evaluation of sequential PET/MRI using a newly developed mobile PET system for brain imaging. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11604-021-01105-9.
The full-text file will be made open to the public on 28 February 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/264259
DOI(Published Version): 10.1007/s11604-021-01105-9
PubMed ID: 33641056
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