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タイトル: | Phospholipid‐flipping activity of P4‐ATPase drives membrane curvature |
著者: | Takada, Naoto Naito, Tomoki Inoue, Takanari Nakayama, Kazuhisa https://orcid.org/0000-0001-7701-7183 (unconfirmed) Takatsu, Hiroyuki Shin, Hye‐Won |
著者名の別形: | 高田, 直人 内藤, 朋樹 中山, 和久 高津, 宏之 申, 惠媛 |
キーワード: | BAR domain curvature flippase lipid plasma membrane |
発行日: | May-2018 |
出版者: | EMBO |
誌名: | The EMBO Journal |
巻: | 37 |
号: | 9 |
論文番号: | e97705 |
抄録: | P4-ATPases are phospholipid flippases that translocate phospholipids from the exoplasmic/luminal to the cytoplasmic leaflet of biological membranes. All P4-ATPases in yeast and some in other organisms are required for membrane trafficking; therefore, changes in the transbilayer lipid composition induced by flippases are thought to be crucial for membrane deformation. However, it is poorly understood whether the phospholipid-flipping activity of P4-ATPases can promote membrane deformation. In this study, we assessed membrane deformation induced by flippase activity via monitoring the extent of membrane tubulation using a system that allows inducible recruitment of Bin/amphiphysin/Rvs (BAR) domains to the plasma membrane (PM). Enhanced phosphatidylcholine-flippase activity at the PM due to expression of ATP10A, a member of the P4-ATPase family, promoted membrane tubulation upon recruitment of BAR domains to the PM. This is the important evidence that changes in the transbilayer lipid composition induced by P4-ATPases can deform biological membranes. |
記述: | リン脂質の移動によって細胞膜が変形するメカニズムを解明 --ウイルス・細菌の細胞への侵入を制御の可能性--. 京都大学プレスリリース. 2018-03-30. |
著作権等: | This is the author’s version of the paper, which has been published in final form at https://doi.org/10.15252/embj.201797705 The full-text file will be made open to the public on 2 November 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/265249 |
DOI(出版社版): | 10.15252/embj.201797705 |
PubMed ID: | 29599178 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2018-03-30 |
出現コレクション: | 学術雑誌掲載論文等 |
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