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dc.contributor.author | Ghilarov, Dmitry | en |
dc.contributor.author | Inaba-Inoue, Satomi | en |
dc.contributor.author | Stepien, Piotr | en |
dc.contributor.author | Qu, Feng | en |
dc.contributor.author | Michalczyk, Elizabeth | en |
dc.contributor.author | Pakosz, Zuzanna | en |
dc.contributor.author | Nomura, Norimichi | en |
dc.contributor.author | Ogasawara, Satoshi | en |
dc.contributor.author | Walker, Graham Charles | en |
dc.contributor.author | Rebuffat, Sylvie | en |
dc.contributor.author | Iwata, So | en |
dc.contributor.author | Heddle, Jonathan Gardiner | en |
dc.contributor.author | Beis, Konstantinos | en |
dc.contributor.alternative | 稲葉, 理美 | ja |
dc.contributor.alternative | 野村, 紀通 | ja |
dc.contributor.alternative | 小笠原, 諭 | ja |
dc.contributor.alternative | 岩田, 想 | ja |
dc.date.accessioned | 2021-09-14T08:34:00Z | - |
dc.date.available | 2021-09-14T08:34:00Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.uri | http://hdl.handle.net/2433/265258 | - |
dc.description | 抗菌ペプチドは細菌の細胞内にどのように取り込まれるのか? --細菌の膜輸送体SbmAの立体構造の解明--. 京都大学プレスリリース. 2021-09-09. | ja |
dc.description.abstract | Antibiotic metabolites and antimicrobial peptides mediate competition between bacterial species. Many of them hijack inner and outer membrane proteins to enter cells. Sensitivity of enteric bacteria to multiple peptide antibiotics is controlled by the single inner membrane protein SbmA. To establish the molecular mechanism of peptide transport by SbmA and related BacA, we determined their cryo–electron microscopy structures at 3.2 and 6 Å local resolution, respectively. The structures show a previously unknown fold, defining a new class of secondary transporters named SbmA-like peptide transporters. The core domain includes conserved glutamates, which provide a pathway for proton translocation, powering transport. The structures show an outward-open conformation with a large cavity that can accommodate diverse substrates. We propose a molecular mechanism for antibacterial peptide uptake paving the way for creation of narrow-targeted therapeutics. | en |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | en |
dc.rights | Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). | en |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.title | Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Science Advances | en |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 37 | - |
dc.relation.doi | 10.1126/sciadv.abj5363 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | eabj5363 | - |
dc.address | Malopolska Centre of Biotechnology, Jagiellonian University | en |
dc.address | Department of Life Sciences, Imperial College London; Rutherford Appleton Laboratory, Research Complex at Harwell; Diffraction and Scattering Division, Japan Synchrotron Radiation Research Institute, SPring-8 | en |
dc.address | Malopolska Centre of Biotechnology, Jagiellonian University | en |
dc.address | Department of Life Sciences, Imperial College London; Rutherford Appleton Laboratory, Research Complex at Harwell | en |
dc.address | Malopolska Centre of Biotechnology, Jagiellonian University | en |
dc.address | Malopolska Centre of Biotechnology, Jagiellonian University; Postgraduate School of Molecular Medicine | en |
dc.address | Department of Cell Biology, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Cell Biology, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Biology, Massachusetts Institute of Technology | en |
dc.address | Molecules of Communication and Adaptation of Microorganisms Laboratory (MCAM, UMR 7245 CNRS-MNHN), Muséum National d'Histoire Naturelle, Sorbonne Universités, Centre National de la Recherche | en |
dc.address | Department of Cell Biology, Graduate School of Medicine, Kyoto University; RIKEN SPring-8 Center; Research Acceleration Program, Membrane Protein Crystallography Project, Japan Science and Technology Agency | en |
dc.address | Malopolska Centre of Biotechnology, Jagiellonian University | en |
dc.address | Department of Life Sciences, Imperial College London; Rutherford Appleton Laboratory, Research Complex at Harwell | en |
dc.identifier.pmid | 34516884 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2021-09-09-0 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 2375-2548 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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