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タイトル: Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequency
著者: Katsura, Yukako  kyouindb  KAKEN_id
Ikemura, Toshimichi
Kajitani, Rei
Toyoda, Atsushi
Itoh, Takehiko
Ogata, Mitsuaki
Miura, Ikuo
Wada, Kennosuke
Wada, Yoshiko
Satta, Yoko
著者名の別形: 桂, 有加子
発行日: Mar-2021
出版者: Life Science Alliance, LLC
誌名: Life Science Alliance
巻: 4
号: 5
論文番号: e202000905
抄録: The Japanese wrinkled frog (Glandirana rugosa) is unique in having both XX-XY and ZZ-ZW types of sex chromosomes within the species. The genome sequencing and comparative genomics with other frogs should be important to understand mechanisms of turnover of sex chromosomes within one species or during a short period. In this study, we analyzed the newly sequenced genome of G. rugosa using a batch-learning self-organizing map which is unsupervised artificial intelligence for oligonucleotide compositions. To clarify genome characteristics of G. rugosa, we compared its short oligonucleotide compositions in all 1-Mb genomic fragments with those of other six frog species (Pyxicephalus adspersus, Rhinella marina, Spea multiplicata, Leptobrachium leishanense, Xenopus laevis, and Xenopus tropicalis). In G. rugosa, we found an Mb-level large size of repeat sequences having a high identity with the W chromosome of the African bullfrog (P. adspersus). Our study concluded that G. rugosa has unique genome characteristics with a high CG frequency, and its genome is assumed to heterochromatinize a large size of genome via methylataion of CG.
著作権等: © 2021 Katsura et al.
This article is available under a Creative Commons License (Attribution 4.0 International).
URI: http://hdl.handle.net/2433/265336
DOI(出版社版): 10.26508/lsa.202000905
PubMed ID: 33712508
出現コレクション:学術雑誌掲載論文等

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