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Title: Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequency
Authors: Katsura, Yukako  kyouindb  KAKEN_id
Ikemura, Toshimichi
Kajitani, Rei
Toyoda, Atsushi
Itoh, Takehiko
Ogata, Mitsuaki
Miura, Ikuo
Wada, Kennosuke
Wada, Yoshiko
Satta, Yoko
Author's alias: 桂, 有加子
Issue Date: Mar-2021
Publisher: Life Science Alliance, LLC
Journal title: Life Science Alliance
Volume: 4
Issue: 5
Thesis number: e202000905
Abstract: The Japanese wrinkled frog (Glandirana rugosa) is unique in having both XX-XY and ZZ-ZW types of sex chromosomes within the species. The genome sequencing and comparative genomics with other frogs should be important to understand mechanisms of turnover of sex chromosomes within one species or during a short period. In this study, we analyzed the newly sequenced genome of G. rugosa using a batch-learning self-organizing map which is unsupervised artificial intelligence for oligonucleotide compositions. To clarify genome characteristics of G. rugosa, we compared its short oligonucleotide compositions in all 1-Mb genomic fragments with those of other six frog species (Pyxicephalus adspersus, Rhinella marina, Spea multiplicata, Leptobrachium leishanense, Xenopus laevis, and Xenopus tropicalis). In G. rugosa, we found an Mb-level large size of repeat sequences having a high identity with the W chromosome of the African bullfrog (P. adspersus). Our study concluded that G. rugosa has unique genome characteristics with a high CG frequency, and its genome is assumed to heterochromatinize a large size of genome via methylataion of CG.
Rights: © 2021 Katsura et al.
This article is available under a Creative Commons License (Attribution 4.0 International).
DOI(Published Version): 10.26508/lsa.202000905
PubMed ID: 33712508
Appears in Collections:Journal Articles

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