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j.resinv.2021.03.005.pdf | 1.15 MB | Adobe PDF | 見る/開く |
タイトル: | Expiratory central airway collapse and symptoms in smokers |
著者: | Tanabe, Naoya https://orcid.org/0000-0002-7481-0212 (unconfirmed) Terada, Kunihiko Shima, Hiroshi Hamakawa, Yoko Shiraishi, Yusuke Shimizu, Kaoruko Sato, Atsuyasu Oguma, Tsuyoshi Sato, Susumu https://orcid.org/0000-0002-9626-1090 (unconfirmed) Hirai, Toyohiro |
著者名の別形: | 田辺, 直也 島, 寛 濱川, 瑶子 白石, 祐介 佐藤, 篤靖 小熊, 毅 佐藤, 晋 平井, 豊博 |
キーワード: | Chronic obstructive pulmonary disease Cigarette smoke Computed tomography Airway Symptom |
発行日: | Jul-2021 |
出版者: | Elsevier BV |
誌名: | Respiratory investigation |
巻: | 59 |
号: | 4 |
開始ページ: | 522 |
終了ページ: | 529 |
抄録: | [Background] The prevalence and clinical impacts of expiratory central airway collapse (ECAC) in smokers remain controversial. Although studies have shown associations of ECAC with airflow limitation and symptoms, others have shown that higher tracheal collapsibility is associated with lower expiratory-to-inspiratory ratio of lung volume (E/I-LV), but not airflow limitation. This study tested whether ECAC of the trachea and main bronchi could occur exclusively in smokers with lower E/I-LV and affect their symptoms independent of emphysema and intrapulmonary airway disease. [Methods] ECAC was defined as the expiratory-to-inspiratory ratio of cross-sectional lumen area <0.5 for at least one of the three locations, including the trachea, right and left main bronchi on static full-inspiratory, and end-tidal expiratory CT. Symptoms were assessed using the chronic obstructive pulmonary disease (COPD) assessment test (CAT) and modified MRC scale (mMRC). [Results] Out of 241 smokers with and without COPD (n = 189 and 52, respectively), ECAC was found in 21 (9%) smokers. No ECAC was found in smokers with E/I-LV ≥0.75. CAT and mMRC in smokers with ECAC were higher than in non-ECAC smokers with E/I-LV <0.75, but comparable to those in non-ECAC smokers with E/I-LV ≥0.75. In the multivariable analysis of smokers with E/I-LV <0.75, ECAC was associated with increased mMRC and CAT independent of CT-emphysema severity, wall area percent of segmental airways, and forced expiratory volume in 1 s [Conclusions] ECAC is associated with worsening of symptoms independent of emphysema and segmental airway disease in smokers with a lower expiratory-to-inspiratory lung volume ratio. |
著作権等: | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 license. The full-text file will be made open to the public on 1 July 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/265346 |
DOI(出版社版): | 10.1016/j.resinv.2021.03.005 |
PubMed ID: | 33883089 |
出現コレクション: | 学術雑誌掲載論文等 |
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