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Title: Isomerization and Epimerization of Galactose to Tagatose and Talose in a Phosphate Buffer Containing Organic Solvents under Subcritical Water Conditions
Authors: Onishi, Yuichiro
Furushiro, Yuya
Adachi, Shuji
Kobayashi, Takashi  kyouindb  KAKEN_id
Author's alias: 小林, 敬
Keywords: ethanol
phosphate buffer
rare sugar
subcritical water
Issue Date: 2021
Publisher: American Chemical Society (ACS)
Journal title: Industrial & Engineering Chemistry Research
Volume: 60
Issue: 14
Start page: 5084
End page: 5089
Abstract: In this study, galactose was treated under subcritical water conditions at 140 °C and 5 MPa in a mixture of 10 mmol/L sodium phosphate buffer (pH 7.0) and ethanol using a tubular reactor. The effects of ethanol concentration (0–60 wt %) on the isomerization and epimerization of galactose, respectively, to tagatose and talose were investigated. Both ethanol and buffer synergistically improved the isomerization behavior. Increasing the ethanol concentration up to 60 wt % improved the tagatose yield from 13 to 16% at 300 s. In contrast, the yield of talose slightly decreased from 1.5 to 1.2% at 300 s when ethanol was added to the phosphate buffer. The pH of treated solution at 25 °C decreased with an increase in the duration of treatment under each treatment condition. However, the decrease in pH was moderately suppressed by the addition of ethanol, which could be one of the reasons for the improvement in tagatose yield. The addition of other organic solvents, such as alkanols, polyols, acetonitrile, and pyridine, also improved the tagatose yield.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Industrial & Engineering Chemistry Research, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
The full-text file will be made open to the public on 14 April 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1021/acs.iecr.1c00682
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