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dc.contributor.author | Toda, Yasuka | en |
dc.contributor.author | Hayakawa, Takashi | en |
dc.contributor.author | Itoigawa, Akihiro | en |
dc.contributor.author | Kurihara, Yosuke | en |
dc.contributor.author | Nakagita, Tomoya | en |
dc.contributor.author | Hayashi, Masahiro | en |
dc.contributor.author | Ashino, Ryuichi | en |
dc.contributor.author | Melin, Amanda D. | en |
dc.contributor.author | Ishimaru, Yoshiro | en |
dc.contributor.author | Kawamura, Shoji | en |
dc.contributor.author | Imai, Hiroo | en |
dc.contributor.author | Misaka, Takumi | en |
dc.contributor.alternative | 戸田, 安香 | ja |
dc.contributor.alternative | 早川, 卓志 | ja |
dc.contributor.alternative | 糸井川, 壮大 | ja |
dc.contributor.alternative | 栗原, 洋介 | ja |
dc.contributor.alternative | 中北, 智哉 | ja |
dc.contributor.alternative | 林, 真広 | ja |
dc.contributor.alternative | 蘆野, 龍一 | ja |
dc.contributor.alternative | 石丸, 喜朗 | ja |
dc.contributor.alternative | 河村, 正二 | ja |
dc.contributor.alternative | 今井, 啓雄 | ja |
dc.contributor.alternative | 三坂, 巧 | ja |
dc.date.accessioned | 2021-10-28T02:48:09Z | - |
dc.date.available | 2021-10-28T02:48:09Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.uri | http://hdl.handle.net/2433/265528 | - |
dc.description | 霊長類におけるグルタミン酸の旨味の起源 --体の大きな霊長類は旨味感覚で葉の苦さを克服--. 京都大学プレスリリース. 2021-08-30. | ja |
dc.description.abstract | Taste perception plays an essential role in food selection. Umami (savory) tastes are sensed by a taste receptor complex, T1R1/T1R3, that detects proteinogenic amino acids. High sensitivity to l-glutamate (l-Glu) is a characteristic of human T1R1/T1R3, but the T1R1/T1R3 of other vertebrates does not consistently show this l-Glu response. Here, we demonstrate that the l-Glu sensitivity of T1R1/T1R3 is a derived state that has evolved repeatedly in large primates that rely on leaves as protein sources, after their divergence from insectivorous ancestors. Receptor expression experiments show that common amino acid substitutions at ligand binding sites that render T1R1/T1R3 sensitive to l-Glu occur independently at least three times in primate evolution. Meanwhile T1R1/T1R3 senses 5′-ribonucleotides as opposed to l-Glu in several mammalian species, including insectivorous primates. Our chemical analysis reveal that l-Glu is one of the major free amino acids in primate diets and that insects, but not leaves, contain large amounts of free 5′-ribonucleotides. Altering the ligand-binding preference of T1R1/T1R3 from 5′-ribonucleotides to l-Glu might promote leaf consumption, overcoming bitter and aversive tastes. Altogether, our results provide insight into the foraging ecology of a diverse mammalian radiation and help reveal how evolution of sensory genes facilitates invasion of new ecological niches. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2021 The Author(s). Published by Elsevier Inc. | en |
dc.rights | This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | umami | en |
dc.subject | taste receptor | en |
dc.subject | T1R1/T1R3 | en |
dc.subject | GPCR | en |
dc.subject | feeding behavior | en |
dc.subject | dietary transition | en |
dc.subject | insectivorous | en |
dc.subject | folivorous | en |
dc.subject | primate evolution | en |
dc.subject | parallel evolution | en |
dc.title | Evolution of the primate glutamate taste sensor from a nucleotide sensor | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Current Biology | en |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 4641 | - |
dc.identifier.epage | 4649 | - |
dc.relation.doi | 10.1016/j.cub.2021.08.002 | - |
dc.textversion | publisher | - |
dc.address | Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo; Department of Agricultural Chemistry, School of Agriculture, Meiji University; Japan Society for the Promotion of Science | en |
dc.address | Faculty of Environmental Earth Science, Hokkaido University; Primate Research Institute, Kyoto University; Japan Monkey Centre | en |
dc.address | Japan Society for the Promotion of Science; Primate Research Institute, Kyoto University | en |
dc.address | Primate Research Institute, Kyoto University; Center for Education and Research in Field Sciences, Faculty of Agriculture, Shizuoka University | en |
dc.address | Department of Agricultural Chemistry, School of Agriculture, Meiji University; Proteo-Science Center, Ehime University | en |
dc.address | Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo | en |
dc.address | Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo | en |
dc.address | Department of Anthropology and Archaeology, University of Calgary; Department of Medical Genetics and Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary | en |
dc.address | Department of Agricultural Chemistry, School of Agriculture, Meiji University | en |
dc.address | Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo | en |
dc.address | Primate Research Institute, Kyoto University | en |
dc.address | Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo | en |
dc.identifier.pmid | 34450087 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2021-08-30 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 18K14427 | - |
datacite.awardNumber | 20H02941 | - |
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datacite.awardNumber | 16H04918 | - |
datacite.awardNumber | 19H02907 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14427/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02941/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12J04270/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18630/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16241/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25257409/ | - |
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dc.identifier.pissn | 0960-9822 | - |
dc.identifier.eissn | 1879-0445 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 旨味受容体の味・栄養素センサーとしての生理的意義解明 | ja |
jpcoar.awardTitle | 旨味受容体の機能と食物成分の関わりの解明 | ja |
jpcoar.awardTitle | 苦味受容体の遺伝的多様性がチンパンジーの地域特異な採食行動にもたらす影響の解明 | ja |
jpcoar.awardTitle | 霊長類におけるゲノム・メタゲノム相関とその進化的意義の解明 | ja |
jpcoar.awardTitle | 採食適応に着目した霊長類と非霊長類哺乳類のゲノム・メタゲノム収斂進化の解明 | ja |
jpcoar.awardTitle | 遺伝・形態学的手法を利用したアフリカ産オナガザル科霊長類の採食戦略の解明 | ja |
jpcoar.awardTitle | ジェントルキツネザルのタケ食適応過程における味覚受容体進化機構の解明 | ja |
jpcoar.awardTitle | 霊長類感覚多重遺伝子族の大規模集団解析による嗅覚・味覚・色覚の総体的進化像の解明 | ja |
jpcoar.awardTitle | 新世界と旧世界の対比による霊長類感覚生態ゲノム学の確立 | ja |
jpcoar.awardTitle | 嗜好味受容体発現細胞を用いた呈味調節物質の探索とその作用機序の解明 | ja |
jpcoar.awardTitle | 客観的呈味測定技術の改良と天然成分由来呈味調節物質の探索 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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