ダウンロード数: 81
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.actaastro.2020.07.002.pdf | 1.18 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Egawa, Tatsuro | en |
dc.contributor.author | Kido, Kohei | en |
dc.contributor.author | Yokokawa, Takumi | en |
dc.contributor.author | Fujibayashi, Mami | en |
dc.contributor.author | Goto, Katsumasa | en |
dc.contributor.author | Hayashi, Tatsuya | en |
dc.contributor.alternative | 江川, 達郎 | ja |
dc.contributor.alternative | 木戸, 康平 | ja |
dc.contributor.alternative | 横川, 拓海 | ja |
dc.contributor.alternative | 林, 達也 | ja |
dc.date.accessioned | 2021-12-06T06:24:26Z | - |
dc.date.available | 2021-12-06T06:24:26Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.uri | http://hdl.handle.net/2433/266463 | - |
dc.description.abstract | The accumulation of advanced glycation end-products (AGEs) may be involved in the mechanism of skeletal muscle atrophy. However, the involvement of the receptor for AGEs (RAGE) axis in microgravity-induced skeletal muscle atrophy has not been investigated. Therefore, the purpose of the present study was to investigate the effect of RAGE inhibition on microgravity-induced skeletal muscle atrophy and the related molecular responses. Male C57BL/6NCr mice subjected to a 1-week hindlimb suspension lead to muscle atrophy in soleus and plantaris but not extensor digitorum longus muscle, accompanied by increases in RAGE expression. However, treatment with a RAGE antagonist (FPS-ZM1, intraperitoneal, 1 mg/kg/day) during hindlimb suspension ameliorated the atrophic responses in soleus muscle. Further, muscle mass inversely correlated with the accumulation of AGEs (methylglyoxal-modified proteins and Nε-(carboxymethyl) lysine-modified proteins) in soleus muscle. The expression of proinflammatory cytokines, tumor necrosis factor-α, interleukin-1β, and interleukin-6 in soleus muscle was enhanced in response to hindlimb suspension, but these changes were attenuated by FPS-ZM1 treatment. Protein ubiquitination and ubiquitin E3 ligase (muscle RING finger 1) expression in soleus muscle were elevated following hindlimb suspension, and these increments were suppressed by FPS-ZM1 treatment. Our findings indicate that the AGE-RAGE axis is upregulated in unloaded atrophied skeletal muscle, and that RAGE inhibition ameliorates microgravity-induced skeletal muscle atrophy by reducing proinflammatory cytokine expression and ubiquitin-proteasome system activation. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | en |
dc.rights | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights | The full-text file will be made open to the public on 01 November 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.subject | RAGE | en |
dc.subject | Interleukin-1 | en |
dc.subject | Interleukin-6 | en |
dc.subject | Methylglyoxal | en |
dc.subject | Tumor necrosis factor-α | en |
dc.subject | Ubiquitin-proteasome system | en |
dc.title | Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Acta Astronautica | en |
dc.identifier.volume | 176 | - |
dc.identifier.spage | 332 | - |
dc.identifier.epage | 340 | - |
dc.relation.doi | 10.1016/j.actaastro.2020.07.002 | - |
dc.textversion | author | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2022-11-01 | - |
datacite.awardNumber | 18H03148 | - |
datacite.awardNumber | 19K22806 | - |
datacite.awardNumber | 18J01392 | - |
datacite.awardNumber | 19K20007 | - |
datacite.awardNumber | 16J10577 | - |
datacite.awardNumber | 18H03160 | - |
datacite.awardNumber | 19K22825 | - |
datacite.awardNumber | 19KK0254 | - |
datacite.awardNumber | 19K11520 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03148/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22806/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18J01392/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K20007/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J10577/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03160/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22825/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19KK0254/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K11520/ | - |
datacite.awardNumber.uri | 筋衛星細胞nicheを標的としたサルコペニア病態解明と克服策の開発 | ja |
datacite.awardNumber.uri | 筋収縮によって即時的に活性化される骨格筋糖輸送を増強・減弱する因子とその分子機構 | ja |
dc.identifier.pissn | 0094-5765 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 糖化ストレスによる運動トレーニング効果の抑制作用の検証 --糖化研究基盤確立に向けて | ja |
jpcoar.awardTitle | カルボニルストレス解毒システムをターゲットとした骨格筋老化抑制の検証 | ja |
jpcoar.awardTitle | 虚血プレコンディショニングによる新規糖代謝改善法の開発 --運動の併用効果に着目して | ja |
jpcoar.awardTitle | 単回レジスタンス運動でインスリン感受性を改善するために --分子制御からのアプローチ | ja |
jpcoar.awardTitle | 運動が海馬の神経・シナプス形態に及ぼす影響の解明 | ja |
jpcoar.awardTitle | ピエゾチャネルによる骨格筋機械的刺激受容とその活性化による新規骨格筋増強策の開発 | ja |
jpcoar.awardTitle | 胃・小腸-骨格筋間に存在する臓器間ネットワークと骨格筋量調節における役割解明 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このリポジトリに保管されているアイテムはすべて著作権により保護されています。