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タイトル: Novel Aza‐Michael Addition‐Asymmetric Protonation to α,β‐Unsaturated Carboxylic Acids with Chiral Thiourea‐Boronic Acid Hybrid Catalysts
著者: Murakami, Hiroki
Yamada, Ayano
Michigami, Kenichi
Takemoto, Yoshiji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1375-3821 (unconfirmed)
著者名の別形: 村上, 弘樹
山田, 彩乃
道上, 健一
竹本, 佳司
キーワード: α, β-unsaturated carboxylic acid
aza-Michael addition
asymmetric protonation
β²-amino acid
total synthesis
発行日: May-2021
出版者: Wiley
誌名: Asian Journal of Organic Chemistry
巻: 10
号: 5
開始ページ: 1097
終了ページ: 1101
抄録: Novel aza-michael addition-asymmetric protonation to unsaturated carboxylic acids with chiral thiourea-boronic acid hybrid catalysts. #asymmetric protonationIn this study, an efficient method has been developed for controlling carbonyl α-chirality with functionalizing β-position by the conjugate addition-asymmetric protonation (CAAP) of α, β-unsaturated carboxylic acids using chiral thiourea-amino boronic acid hybrid catalysts. In addition, the method is applied to the asymmetric synthesis of biologically active compounds.
著作権等: This is the peer reviewed version of the following article: H. Murakami, A. Yamada, K. Michigami, Y. Takemoto, Asian J. Org. Chem. 2021, 10(5), 1097-1101, which has been published in final form at https://doi.org/10.1002/ajoc.202100145. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
The full-text file will be made open to the public on 16 April 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/266608
DOI(出版社版): 10.1002/ajoc.202100145
出現コレクション:学術雑誌掲載論文等

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